Alianza FC (SLV) 0-4 Philadelphia Union *
| 15.03.2023 | Philadelphia Union | 4-0 | Alianza FC (SLV) | |
| 08.03.2023 | Alianza FC (SLV) | 0-0 | Philadelphia Union | |
*CD Motagua 1-1 Pachuca CF
| 17.03.2023 | Pachuca CF | 1-1 | CD Motagua | |
| 10.03.2023 | CD Motagua | 0-0 | Pachuca CF | |
CD Olimpia 4-5 Club Atlas *
| 15.03.2023 | Club Atlas | 4-0 | CD Olimpia | |
| 09.03.2023 | CD Olimpia | 4-1 | Club Atlas | |
LD Alajuelense 2-4 Los Angeles FC *
| 16.03.2023 | Los Angeles FC | 1-2 | LD Alajuelense | |
| 10.03.2023 | LD Alajuelense | 0-3 | Los Angeles FC | |
*Tigres UANL 1-1 Orlando City SC
| 16.03.2023 | Orlando City SC | 1-1 | Tigres UANL | |
| 08.03.2023 | Tigres UANL | 0-0 | Orlando City SC | |
*Vancouver WC 7-3 Real España
| 15.03.2023 | Real España | 3-2 | Vancouver WC | |
| 09.03.2023 | Vancouver WC | 5-0 | Real España | |
*Violette AC 3-2 Austin FC
| 15.03.2023 | Austin FC | 2-0 | Violette AC | |
| 08.03.2023 | Violette AC | 3-0 | Austin FC | |