*Athletico/PR 3-2 Club Libertad
| 06.07.2022 | Club Libertad | 1-1 | Athletico/PR | |
| 29.06.2022 | Athletico/PR | 2-1 | Club Libertad | |
*Corinthians/SP 0-0 Boca Juniors
| 06.07.2022 | Boca Juniors | 0-0/p.5-6 | Corinthians/SP | |
| 29.06.2022 | Corinthians/SP | 0-0 | Boca Juniors | |
Cerro Porteño 0-8 Palmeiras/SP *
| 07.07.2022 | Palmeiras/SP | 5-0 | Cerro Porteño | |
| 30.06.2022 | Cerro Porteño | 0-3 | Palmeiras/SP | |
*Talleres Córdoba 3-1 Colon Santa Fe
| 07.07.2022 | Colon Santa Fe | 0-2 | Talleres Córdoba | |
| 30.06.2022 | Talleres Córdoba | 1-1 | Colon Santa Fe | |
CS Emelec 1-2 Atlético Mineiro/MG *
| 06.07.2022 | Atlético Mineiro/MG | 1-0 | CS Emelec | |
| 29.06.2022 | CS Emelec | 1-1 | Atlético Mineiro/MG | |
Deportes Tolima 1-8 Flamengo/RJ *
| 07.07.2022 | Flamengo/RJ | 7-1 | Deportes Tolima | |
| 30.06.2022 | Deportes Tolima | 0-1 | Flamengo/RJ | |
Fortaleza/CE 1-4 Estudiantes La Plata *
| 08.07.2022 | Estudiantes La Plata | 3-0 | Fortaleza/CE | |
| 01.07.2022 | Fortaleza/CE | 1-1 | Estudiantes La Plata | |
*Vélez Sársfield 1-0 River Plate
| 07.07.2022 | River Plate | 0-0 | Vélez Sársfield | |
| 30.06.2022 | Vélez Sársfield | 1-0 | River Plate | |