*Athletico/PR 2-0 Santos/SP
| 15.09.2021 | Santos/SP | 0-1 | Athletico/PR | |
| 26.08.2021 | Athletico/PR | 1-0 | Santos/SP | |
Fluminense/RJ 1-3 Atlético Mineiro/MG *
| 16.09.2021 | Atlético Mineiro/MG | 1-0 | Fluminense/RJ | |
| 27.08.2021 | Fluminense/RJ | 1-2 | Atlético Mineiro/MG | |
Grêmio/RS 0-6 Flamengo/RJ *
| 16.09.2021 | Flamengo/RJ | 2-0 | Grêmio/RS | |
| 26.08.2021 | Grêmio/RS | 0-4 | Flamengo/RJ | |
São Paulo/SP 3-5 Fortaleza/CE *
| 16.09.2021 | Fortaleza/CE | 3-1 | São Paulo/SP | |
| 26.08.2021 | São Paulo/SP | 2-2 | Fortaleza/CE | |