UNAM Pumas 2-6 Club América *
| 06.05.2018 | Club América | 2-1 | UNAM Pumas | |
| 03.05.2018 | UNAM Pumas | 1-4 | Club América | |
*Club Tijuana 3-2 CF Monterrey
| 06.05.2018 | CF Monterrey | 1-2 | Club Tijuana | |
| 03.05.2018 | Club Tijuana | 1-1 | CF Monterrey | |
Monarcas Morelia 4-4 Deportivo Toluca *
| 06.05.2018 | Deportivo Toluca | 2-2 | Monarcas Morelia | |
| 04.05.2018 | Monarcas Morelia | 2-2 | Deportivo Toluca | |
Tigres UANL 2-2 Santos Laguna *
| 07.05.2018 | Santos Laguna | 2-0 | Tigres UANL | |
| 04.05.2018 | Tigres UANL | 2-0 | Santos Laguna | |