Club Puebla 2-3 Club León *
| 29.11.2020 | Club León | 2-0 | Club Puebla | |
| 26.11.2020 | Club Puebla | 2-1 | Club León | |
*Guadalajara Chivas 3-1 Club América
| 29.11.2020 | Club América | 1-2 | Guadalajara Chivas | |
| 26.11.2020 | Guadalajara Chivas | 1-0 | Club América | |
Pachuca CF 0-1 UNAM Pumas *
| 29.11.2020 | UNAM Pumas | 0-0 | Pachuca CF | |
| 27.11.2020 | Pachuca CF | 0-1 | UNAM Pumas | |
Tigres UANL 2-3 Cruz Azul *
| 30.11.2020 | Cruz Azul | 0-1 | Tigres UANL | |
| 27.11.2020 | Tigres UANL | 1-3 | Cruz Azul | |