*AC Libertas 8-0 FC Domagnano
| 07.05.2022 | FC Domagnano | 0-3 | AC Libertas | |
| 03.05.2022 | AC Libertas | 5-0 | FC Domagnano | |
Folgore Calcio 2-3 FC Fiorentino *
| 07.05.2022 | FC Fiorentino | 1-2 | Folgore Calcio | |
| 03.05.2022 | Folgore Calcio | 0-2 | FC Fiorentino | |
*SC Faetano 3-2 SS San Giovanni
| 07.05.2022 | SS San Giovanni | 1-2 | SC Faetano | |
| 03.05.2022 | SC Faetano | 1-1 | SS San Giovanni | |
*SS Pennarossa 3-2 SS Murata
| 07.05.2022 | SS Murata | 1-2 | SS Pennarossa | |
| 03.05.2022 | SS Pennarossa | 1-1 | SS Murata | |