CA Banfield 2-3 Nacional (URU) *
| 22.02.2018 | Nacional (URU) | 1-0 | CA Banfield | |
| 14.02.2018 | CA Banfield | 2-2 | Nacional (URU) | |
*Junior Barranquilla 1-0 Club Guaraní
| 23.02.2018 | Club Guaraní | 0-0 | Junior Barranquilla | |
| 15.02.2018 | Junior Barranquilla | 1-0 | Club Guaraní | |
Santiago Wanderers 1-5 Ind. Santa Fe *
| 21.02.2018 | Ind. Santa Fe | 3-0 | Santiago Wanderers | |
| 14.02.2018 | Santiago Wanderers | 1-2 | Ind. Santa Fe | |
*Vasco da Gama/RJ 4-4 Jorge Wilstermann
| 22.02.2018 | Jorge Wilstermann | 4-0/p.2-3 | Vasco da Gama/RJ | |
| 15.02.2018 | Vasco da Gama/RJ | 4-0 | Jorge Wilstermann | |