*Bayer Leverkusen 5-5 AS Monaco
| 23.02.2023 | AS Monaco | 2-3/p.3-5 | Bayer Leverkusen | |
| 16.02.2023 | Bayer Leverkusen | 2-3 | AS Monaco | |
FC Barcelona 3-4 Manchester United *
| 23.02.2023 | Manchester United | 2-1 | FC Barcelona | |
| 16.02.2023 | FC Barcelona | 2-2 | Manchester United | |
*Sporting Lisboa 5-1 FC Midtjylland
| 23.02.2023 | FC Midtjylland | 0-4 | Sporting Lisboa | |
| 16.02.2023 | Sporting Lisboa | 1-1 | FC Midtjylland | |
*Juventus FC 4-1 FC Nantes
| 23.02.2023 | FC Nantes | 0-3 | Juventus FC | |
| 16.02.2023 | Juventus FC | 1-1 | FC Nantes | |
*Sevilla FC 3-2 PSV Eindhoven
| 23.02.2023 | PSV Eindhoven | 2-0 | Sevilla FC | |
| 16.02.2023 | Sevilla FC | 3-0 | PSV Eindhoven | |
RB Salzburg 1-2 AS Roma *
| 23.02.2023 | AS Roma | 2-0 | RB Salzburg | |
| 16.02.2023 | RB Salzburg | 1-0 | AS Roma | |
*Shakhtar Donetsk 3-3 Stade Rennais
| 23.02.2023 | Stade Rennais | 2-1/p.4-5 | Shakhtar Donetsk | |
| 16.02.2023 | Shakhtar Donetsk | 2-1 | Stade Rennais | |
AFC Ajax 1-3 Union Berlin *
| 23.02.2023 | Union Berlin | 3-1 | AFC Ajax | |
| 16.02.2023 | AFC Ajax | 0-0 | Union Berlin | |