Bordeaux Youth 0-5 RB Salzburg Youth *
| 17.10.2017 | RB Salzburg Youth | 4-0 | Bordeaux Youth | |
| 26.09.2017 | Bordeaux Youth | 0-1 | RB Salzburg Youth | |
Bursaspor Youth 1-2 Saburtalo Youth *
| 18.10.2017 | Saburtalo Youth | 1-1 | Bursaspor Youth | |
| 27.09.2017 | Bursaspor Youth | 0-1 | Saburtalo Youth | |
Dinamo Bucureşti Youth 2-4 Lokomotiva Z. Youth *
| 18.10.2017 | Lokomotiva Z. Youth | 2-2 | Dinamo Bucureşti Youth | |
| 26.09.2017 | Dinamo Bucureşti Youth | 0-2 | Lokomotiva Z. Youth | |
KäPa Youth 2-4 Esbjerg fB Youth *
| 18.10.2017 | Esbjerg fB Youth | 2-1 | KäPa Youth | |
| 27.09.2017 | KäPa Youth | 1-2 | Esbjerg fB Youth | |
F91 Dudelange Youth 1-7 Sparta Praha Youth *
| 18.10.2017 | Sparta Praha Youth | 3-1 | F91 Dudelange Youth | |
| 27.09.2017 | F91 Dudelange Youth | 0-4 | Sparta Praha Youth | |
Kairat Almaty Akademiya 2-11 FK Krasnodar Youth *
| 18.10.2017 | FK Krasnodar Youth | 9-0 | Kairat Almaty Akademiya | |
| 27.09.2017 | Kairat Almaty Akademiya | 2-2 | FK Krasnodar Youth | |
Hammarby IF Youth 0-6 AFC Ajax Youth *
| 17.10.2017 | AFC Ajax Youth | 2-0 | Hammarby IF Youth | |
| 26.09.2017 | Hammarby IF Youth | 0-4 | AFC Ajax Youth | |
Sutjeska N. Youth 2-3 Honved-MFA U19 *
| 18.10.2017 | Honved-MFA U19 | 1-0 | Sutjeska N. Youth | |
| 27.09.2017 | Sutjeska N. Youth | 2-2 | Honved-MFA U19 | |
*Inter Milan Youth 5-2 Dynamo Kyiv Youth
| 18.10.2017 | Dynamo Kyiv Youth | 0-3 | Inter Milan Youth | |
| 27.09.2017 | Inter Milan Youth | 2-2 | Dynamo Kyiv Youth | |
Breidablik Youth 1-3 Legia Youth *
| 17.10.2017 | Legia Youth | 0-0 | Breidablik Youth | |
| 27.09.2017 | Breidablik Youth | 1-3 | Legia Youth | |
Ludogorets Youth 3-4 Zeljeznicar Youth *
| 18.10.2017 | Zeljeznicar Youth | 3-2 | Ludogorets Youth | |
| 27.09.2017 | Ludogorets Youth | 1-1 | Zeljeznicar Youth | |
*FK Brodarac Youth 2-1 Maccabi Haifa Youth
| 18.10.2017 | Maccabi Haifa Youth | 0-1 | FK Brodarac Youth | |
| 27.09.2017 | FK Brodarac Youth | 1-1 | Maccabi Haifa Youth | |
UCD Youth 3-3 Molde Youth *
| 18.10.2017 | Molde Youth | 2-1/p.5-4 | UCD Youth | |
| 27.09.2017 | UCD Youth | 2-1 | Molde Youth | |
FK Liepaja Youth 2-4 Shakhter Solig. Youth *
| 17.10.2017 | Shakhter Solig. Youth | 3-0 | FK Liepaja Youth | |
| 27.09.2017 | FK Liepaja Youth | 2-1 | Shakhter Solig. Youth | |
*FC Nitra Youth 2-1 Shkendija'79 Youth
| 17.10.2017 | Shkendija'79 Youth | 1-1 | FC Nitra Youth | |
| 27.09.2017 | FC Nitra Youth | 1-0 | Shkendija'79 Youth | |
*Zimbru Youth 7-3 Vllaznia Youth
| 18.10.2017 | Vllaznia Youth | 2-4 | Zimbru Youth | |
| 26.09.2017 | Zimbru Youth | 3-1 | Vllaznia Youth | |