*Atlético/MG U20 7-2 Galvez/AC U20
| 10.05.2021 | Galvez/AC U20 | 2-2 | Atlético/MG U20 | |
| 05.05.2021 | Atlético/MG U20 | 5-0 | Galvez/AC U20 | |
ABC/RN U20 3-3 Avaí FC/SC U20 *
| 09.05.2021 | Avaí FC/SC U20 | 0-3/p.2-0 | ABC/RN U20 | |
| 05.05.2021 | ABC/RN U20 | 0-3 | Avaí FC/SC U20 | |
*Botafogo/RJ U20 3-1 São José PoA/RS U20
| 09.05.2021 | São José PoA/RS U20 | 1-1 | Botafogo/RJ U20 | |
| 05.05.2021 | Botafogo/RJ U20 | 2-0 | São José PoA/RS U20 | |
*Coritiba/PR U20 3-2 Bahia/BA U20
| 10.05.2021 | Bahia/BA U20 | 2-2 | Coritiba/PR U20 | |
| 05.05.2021 | Coritiba/PR U20 | 1-0 | Bahia/BA U20 | |
Tupi/MG U20 1-9 Internacional/RS U20 *
| 08.05.2021 | Internacional/RS U20 | 5-0 | Tupi/MG U20 | |
| 05.05.2021 | Tupi/MG U20 | 1-4 | Internacional/RS U20 | |
*Palmeiras/SP U20 6-1 Náutico/PE U20
| 09.05.2021 | Náutico/PE U20 | 1-2 | Palmeiras/SP U20 | |
| 06.05.2021 | Palmeiras/SP U20 | 4-0 | Náutico/PE U20 | |
São Raimundo/RR U20 3-7 Vasco/RJ U20 *
| 09.05.2021 | Vasco/RJ U20 | 4-2 | São Raimundo/RR U20 | |
| 05.05.2021 | São Raimundo/RR U20 | 1-3 | Vasco/RJ U20 | |
Uniao ABC/MS U20 1-7 Floresta/CE U20 *
| 12.05.2021 | Floresta/CE U20 | 5-0 | Uniao ABC/MS U20 | |
| 05.05.2021 | Uniao ABC/MS U20 | 1-2 | Floresta/CE U20 | |