Alianza Petrolera 0-6 Independiente Medellín *
| 07.12.2015 | Independiente Medellín | 4-0 | Alianza Petrolera | |
| 30.11.2015 | Alianza Petrolera | 0-2 | Independiente Medellín | |
Deportivo Cali 1-3 Atlético Nacional *
| 06.12.2015 | Atlético Nacional | 3-1 | Deportivo Cali | |
| 29.11.2015 | Deportivo Cali | 0-0 | Atlético Nacional | |
Ind. Santa Fe 3-4 Junior Barranquilla *
| 06.12.2015 | Junior Barranquilla | 3-1 | Ind. Santa Fe | |
| 29.11.2015 | Ind. Santa Fe | 2-1 | Junior Barranquilla | |
Once Caldas 2-3 Deportes Tolima *
| 05.12.2015 | Deportes Tolima | 3-1 | Once Caldas | |
| 28.11.2015 | Once Caldas | 1-0 | Deportes Tolima | |