Alebrijes de Oaxaca 1-1 Atlante FC *
| 19.11.2018 | Atlante FC | 0-0 | Alebrijes de Oaxaca | |
| 16.11.2018 | Alebrijes de Oaxaca | 1-1 | Atlante FC | |
*Atlético San Luis 3-1 Cimarrones Sonora
| 19.11.2018 | Cimarrones Sonora | 1-3 | Atlético San Luis | |
| 16.11.2018 | Atlético San Luis | 0-0 | Cimarrones Sonora | |
*Dorados Sinaloa 1-0 Mineros de Zacatecas
| 17.11.2018 | Mineros de Zacatecas | 0-1 | Dorados Sinaloa | |
| 15.11.2018 | Dorados Sinaloa | 0-0 | Mineros de Zacatecas | |
Leones Negros 2-2 FC Juárez *
| 18.11.2018 | FC Juárez | 1-1 | Leones Negros | |
| 15.11.2018 | Leones Negros | 1-1 | FC Juárez | |