Club León 2-5 Club América *
| 06.05.2001 | Club América | 4-1 | Club León | |
| 03.05.2001 | Club León | 1-1 | Club América | |
*Pachuca CF 6-2 CF Monterrey
| 06.05.2001 | CF Monterrey | 2-2 | Pachuca CF | |
| 03.05.2001 | Pachuca CF | 4-0 | CF Monterrey | |
*Puebla FC 5-3 Tigres UANL
| 06.05.2001 | Tigres UANL | 2-2 | Puebla FC | |
| 02.05.2001 | Puebla FC | 3-1 | Tigres UANL | |
Tecos A 2-7 Santos Laguna *
| 06.05.2001 | Santos Laguna | 4-0 | Tecos A | |
| 04.05.2001 | Tecos A | 2-3 | Santos Laguna | |