*Al Amal Atbara 4-0 KVZ FC
| 27.11.2020 | Al Amal Atbara | 1-0 | KVZ FC | |
| 05.12.2020 | KVZ FC | 0-3 | Al Amal Atbara | |
CI Kamsar 0-1 Renaissance (CHA) *
| 27.11.2020 | CI Kamsar | 0-0 | Renaissance (CHA) | |
| 06.12.2020 | Renaissance (CHA) | 1-0 | CI Kamsar | |
*US Monastir 3-2 Fasil Kenema
| 27.11.2020 | US Monastir | 2-0 | Fasil Kenema | |
| 06.12.2020 | Fasil Kenema | 2-1 | US Monastir | |
Musongati FC 3-4 Green Eagles *
| 28.11.2020 | Musongati FC | 2-2 | Green Eagles | |
| 06.12.2020 | Green Eagles | 2-1 | Musongati FC | |
AS Arta 1-10 Al Mokawloon Al Arab *
| 28.11.2020 | AS Arta | 0-1 | Al Mokawloon Al Arab | |
| 04.12.2020 | Al Mokawloon Al Arab | 9-1 | AS Arta | |
Étoile du Congo 1-1 Bravos do Maquis *
| 28.11.2020 | Étoile du Congo | 1-1 | Bravos do Maquis | |
| 06.12.2020 | Bravos do Maquis | 0-0 | Étoile du Congo | |
Futuro Kings 3-3 Rivers United *
| 28.11.2020 | Futuro Kings | 2-1 | Rivers United | |
| 06.12.2020 | Rivers United | 2-1/p.2-0 | Futuro Kings | |
*Al Ittihad Tripoli 7-1 Horseed FC
| 28.11.2020 | Al Ittihad Tripoli | 4-1 | Horseed FC | |
| 06.12.2020 | Horseed FC | 0-3 | Al Ittihad Tripoli | |
*Namungo FC 5-0 Al Rabita Juba
| 28.11.2020 | Namungo FC | 3-0 | Al Rabita Juba | |
| 06.12.2020 | Al Rabita Juba | 0-2 W.O. | Namungo FC | |
AS Kaloum Star 1-2 FC Tevragh-Zeina *
| 28.11.2020 | AS Kaloum Star | 1-1 | FC Tevragh-Zeina | |
| 06.12.2020 | FC Tevragh-Zeina | 1-0 | AS Kaloum Star | |
*ASC Jaraaf 3-1 Kano Pillars
| 28.11.2020 | ASC Jaraaf | 3-1 | Kano Pillars | |
| 05.12.2020 | Kano Pillars | 0-0 | ASC Jaraaf | |
GAMTEL FC 0-3 TAS Casablanca *
| 28.11.2020 | GAMTEL FC | 0-1 | TAS Casablanca | |
| 05.12.2020 | TAS Casablanca | 2-0 W.O. | GAMTEL FC | |
*Sagrada Esperanca 4-0 Mbabane Swallows
| 29.11.2020 | Sagrada Esperanca | 2-0 W.O. | Mbabane Swallows | |
| 06.12.2020 | Mbabane Swallows | 0-2 W.O. | Sagrada Esperanca | |
AS Maniema Union 2-2 Bloemfontein Celtic *
| 29.11.2020 | AS Maniema Union | 0-2 | Bloemfontein Celtic | |
| 05.12.2020 | Bloemfontein Celtic | 0-2/p.3-2 | AS Maniema Union | |
Ngazi Sport 2-9 NAPSA Stars *
| 29.11.2020 | Ngazi Sport | 1-5 | NAPSA Stars | |
| 05.12.2020 | NAPSA Stars | 4-1 | Ngazi Sport | |
Orapa United 2-2 Kigali FC *
| 29.11.2020 | Orapa United | 2-1 | Kigali FC | |
| 06.12.2020 | Kigali FC | 1-0 | Orapa United | |
Ashanti Gold SC 1-2 Salitas FC *
| 29.11.2020 | Ashanti Gold SC | 0-0 | Salitas FC | |
| 05.12.2020 | Salitas FC | 2-1 | Ashanti Gold SC | |
Unisport Sokode 1-2 Coton Sport *
| 29.11.2020 | Unisport Sokode | 0-2 | Coton Sport | |
| 06.12.2020 | Coton Sport | 0-1 | Unisport Sokode | |
Yeelen Olympique 1-2 US GN *
| 29.11.2020 | Yeelen Olympique | 0-1 | US GN | |
| 05.12.2020 | US GN | 1-1 | Yeelen Olympique | |