Foresters MF FC 1-4 15 de Agosto (EQG) *
| 16.09.2025 | Foresters MF FC | 1-0 | 15 de Agosto (EQG) | |
| 21.09.2025 | 15 de Agosto (EQG) | 4-0 | Foresters MF FC | |
Wolaitta Dicha 1-3 Al Ittihad Tripoli *
| 19.09.2025 | Wolaitta Dicha | 0-0 | Al Ittihad Tripoli | |
| 26.09.2025 | Al Ittihad Tripoli | 3-1 | Wolaitta Dicha | |
Aigle Royal Menoua 2-3 FC San Pédro *
| 19.09.2025 | Aigle Royal Menoua | 0-1 | FC San Pédro | |
| 27.09.2025 | FC San Pédro | 2-2 | Aigle Royal Menoua | |
AS NIGELEC 0-6 Olympique Safi *
| 19.09.2025 | AS NIGELEC | 0-1 | Olympique Safi | |
| 27.09.2025 | Olympique Safi | 5-0 | AS NIGELEC | |
*US Forces Armées 3-0 Gbohloé-Su des Lacs
| 19.09.2025 | US Forces Armées | 1-0 | Gbohloé-Su des Lacs | |
| 28.09.2025 | Gbohloé-Su des Lacs | 0-2 | US Forces Armées | |
*Flambeau du Centre 4-3 Al Akhdar SC
| 20.09.2025 | Flambeau du Centre | 2-1 | Al Akhdar SC | |
| 28.09.2025 | Al Akhdar SC | 2-2 | Flambeau du Centre | |
Al Merreikh Juba 0-4 Azam FC *
| 20.09.2025 | Al Merreikh Juba | 0-2 | Azam FC | |
| 28.09.2025 | Azam FC | 2-0 | Al Merreikh Juba | |
Ahli Wad Madani 1-3 Étoile Sahel Sousse *
| 20.09.2025 | Ahli Wad Madani | 1-0 | Étoile Sahel Sousse | |
| 27.09.2025 | Étoile Sahel Sousse | 3-0 | Ahli Wad Madani | |
Young Africans (NAM) 0-7 Royal Leopards *
| 20.09.2025 | Young Africans (NAM) | 0-2 | Royal Leopards | |
| 26.09.2025 | Royal Leopards | 5-0 | Young Africans (NAM) | |
Kabuscorp SC 1-1 Kaizer Chiefs *
| 20.09.2025 | Kabuscorp SC | 1-0 | Kaizer Chiefs | |
| 27.09.2025 | Kaizer Chiefs | 1-0/p.5-4 | Kabuscorp SC | |
FC 105 Libreville 2-5 ZESCO United *
| 20.09.2025 | FC 105 Libreville | 2-0 | ZESCO United | |
| 28.09.2025 | ZESCO United | 5-0 | FC 105 Libreville | |
Bhantal FC 3-5 Hafia FC *
| 20.09.2025 | Bhantal FC | 0-3 | Hafia FC | |
| 26.09.2025 | Hafia FC | 2-3 | Bhantal FC | |
NEC FC (UGA) 3-3 Nairobi United FC *
| 20.09.2025 | NEC FC (UGA) | 2-2 | Nairobi United FC | |
| 27.09.2025 | Nairobi United FC | 1-1 | NEC FC (UGA) | |
Rayon Sports 1-3 Singida Black Stars *
| 20.09.2025 | Rayon Sports | 0-1 | Singida Black Stars | |
| 27.09.2025 | Singida Black Stars | 2-1 | Rayon Sports | |
*Stade Tunisien 2-0 ASC SNIM
| 20.09.2025 | Stade Tunisien | 2-0 | ASC SNIM | |
| 27.09.2025 | ASC SNIM | 0-0 | Stade Tunisien | |
*Dekedaha FC 2-2 Al Zamala SC
| 21.09.2025 | Dekedaha FC | 1-0 | Al Zamala SC | |
| 27.09.2025 | Al Zamala SC | 2-1 | Dekedaha FC | |
*Ferroviário de Maputo 3-2 AS Fanalamanga
| 21.09.2025 | Ferroviário de Maputo | 1-1 | AS Fanalamanga | |
| 26.09.2025 | AS Fanalamanga | 1-2 | Ferroviário de Maputo | |
Mighty Wanderers 1-1 Jwaneng Galaxy *
| 21.09.2025 | Mighty Wanderers | 1-0 | Jwaneng Galaxy | |
| 27.09.2025 | Jwaneng Galaxy | 1-0/p.7-6 | Mighty Wanderers | |
1º de Agosto 1-2 AS Otôho *
| 21.09.2025 | 1º de Agosto | 1-2 | AS Otôho | |
| 28.09.2025 | AS Otôho | 0-0 | 1º de Agosto | |
*Asante Kotoko 5-3 Kwara United
| 21.09.2025 | Asante Kotoko | 4-3 | Kwara United | |
| 28.09.2025 | Kwara United | 0-1 | Asante Kotoko | |
Abia Warriors 1-2 Djoliba AC *
| 21.09.2025 | Abia Warriors | 1-1 | Djoliba AC | |
| 28.09.2025 | Djoliba AC | 1-0 | Abia Warriors | |
Black Man Warriors 1-4 Coton de Ouidah *
| 21.09.2025 | Black Man Warriors | 0-0 | Coton de Ouidah | |
| 26.09.2025 | Coton de Ouidah | 4-1 | Black Man Warriors | |
AS Génération Foot 4-6 AFAD Plateau *
| 21.09.2025 | AS Génération Foot | 1-1 | AFAD Plateau | |
| 27.09.2025 | AFAD Plateau | 5-3 | AS Génération Foot | |
*AS Maniema Union 4-3 Pamplemousses
| 27.09.2025 | AS Maniema Union | 2-1 | Pamplemousses | |
| 04.10.2025 | Pamplemousses | 2-2 | AS Maniema Union | |
*AS Simba (DRC) 3-0 Djabal Club
| 28.09.2025 | AS Simba (DRC) | 1-0 | Djabal Club | |
| 04.10.2025 | Djabal Club | 0-2 | AS Simba (DRC) | |