*CS Cartaginés 4-1 CD Motagua
| 22.10.2025 | CS Cartaginés | 1-0 | CD Motagua | |
| 29.10.2025 | CD Motagua | 1-3 | CS Cartaginés | |
*Sporting San Miguelito 4-2 CD Plaza Amador
| 23.10.2025 | Sporting San Miguelito | 1-0 | CD Plaza Amador | |
| 30.10.2025 | CD Plaza Amador | 2-3 | Sporting San Miguelito | |