Mineros Guyana 1-5 América de Cali *
| 08.02.2005 | América de Cali | 3-1 | Mineros Guyana | |
| 01.02.2005 | Mineros Guyana | 0-2 | América de Cali | |
*Guadalajara Chivas 8-2 Cienciano
| 09.02.2005 | Cienciano | 1-5 | Guadalajara Chivas | |
| 02.02.2005 | Guadalajara Chivas | 3-1 | Cienciano | |
*Junior Barranquilla 5-2 Oriente Petrolero
| 10.02.2005 | Oriente Petrolero | 1-3 | Junior Barranquilla | |
| 03.02.2005 | Junior Barranquilla | 2-1 | Oriente Petrolero | |
*LDU Quito 4-4 CA Peñarol
| 10.02.2005 | CA Peñarol | 4-1 | LDU Quito | |
| 03.02.2005 | LDU Quito | 3-0 | CA Peñarol | |
*Quilmes AC 2-2 Colo Colo
| 08.02.2005 | Colo Colo | 2-2 | Quilmes AC | |
| 01.02.2005 | Quilmes AC | 0-0 | Colo Colo | |
Tacuary FBC 2-4 Palmeiras/SP *
| 09.02.2005 | Palmeiras/SP | 2-0 | Tacuary FBC | |
| 02.02.2005 | Tacuary FBC | 2-2 | Palmeiras/SP | |