Atlético Nacional 1-2 Vélez Sársfield *
| 09.05.2012 | Vélez Sársfield | 1-1 | Atlético Nacional | |
| 02.05.2012 | Atlético Nacional | 0-1 | Vélez Sársfield | |
*Vasco da Gama/RJ 3-3 CA Lanús
| 10.05.2012 | CA Lanús | 2-1/p.4-5 | Vasco da Gama/RJ | |
| 03.05.2012 | Vasco da Gama/RJ | 2-1 | CA Lanús | |
Cruz Azul 1-3 Club Libertad *
| 09.05.2012 | Club Libertad | 2-0 | Cruz Azul | |
| 02.05.2012 | Cruz Azul | 1-1 | Club Libertad | |
CS Emelec 0-3 Corinthians/SP *
| 10.05.2012 | Corinthians/SP | 3-0 | CS Emelec | |
| 03.05.2012 | CS Emelec | 0-0 | Corinthians/SP | |
Deportivo Quito 4-7 Univ de Chile *
| 11.05.2012 | Univ de Chile | 6-0 | Deportivo Quito | |
| 04.05.2012 | Deportivo Quito | 4-1 | Univ de Chile | |
Internacional/RS 1-2 Fluminense/RJ *
| 11.05.2012 | Fluminense/RJ | 2-1 | Internacional/RS | |
| 26.04.2012 | Internacional/RS | 0-0 | Fluminense/RJ | |
*Boca Juniors 5-3 Unión Española
| 10.05.2012 | Unión Española | 2-3 | Boca Juniors | |
| 03.05.2012 | Boca Juniors | 2-1 | Unión Española | |