CA Huracán 0-1 Sporting Cristal *
| 17.03.2023 | Sporting Cristal | 1-0 | CA Huracán | |
| 10.03.2023 | CA Huracán | 0-0 | Sporting Cristal | |
CD Magallanes 1-3 Independiente Medellín *
| 16.03.2023 | Independiente Medellín | 2-0 | CD Magallanes | |
| 08.03.2023 | CD Magallanes | 1-1 | Independiente Medellín | |
Fortaleza/CE 1-3 Cerro Porteño *
| 16.03.2023 | Cerro Porteño | 2-1 | Fortaleza/CE | |
| 09.03.2023 | Fortaleza/CE | 0-1 | Cerro Porteño | |
Millonarios 2-4 Atlético Mineiro/MG *
| 16.03.2023 | Atlético Mineiro/MG | 3-1 | Millonarios | |
| 09.03.2023 | Millonarios | 1-1 | Atlético Mineiro/MG | |