*Atlético/PR 1-0 Brasília FC/DF
| 01.10.2015 | Brasília FC/DF | 0-0 | Atlético/PR | |
| 24.09.2015 | Atlético/PR | 1-0 | Brasília FC/DF | |
Sport Recife/PE 1-4 CA Huracán *
| 01.10.2015 | CA Huracán | 3-0 | Sport Recife/PE | |
| 24.09.2015 | Sport Recife/PE | 1-1 | CA Huracán | |
CA Lanús 0-0 Defensor Sporting *
| 02.10.2015 | Defensor Sporting | 0-0/p.5-3 | CA Lanús | |
| 25.09.2015 | CA Lanús | 0-0 | Defensor Sporting | |
Club Libertad 2-2 Chapecoense/SC *
| 02.10.2015 | Chapecoense/SC | 1-1/p.5-3 | Club Libertad | |
| 25.09.2015 | Club Libertad | 1-1 | Chapecoense/SC | |
Deportes Tolima 1-2 Sportivo Luqueño *
| 30.09.2015 | Sportivo Luqueño | 1-0 | Deportes Tolima | |
| 23.09.2015 | Deportes Tolima | 1-1 | Sportivo Luqueño | |
CS Emelec 2-2 Ind. Santa Fe *
| 30.09.2015 | Ind. Santa Fe | 1-0 | CS Emelec | |
| 24.09.2015 | CS Emelec | 2-1 | Ind. Santa Fe | |
*Independiente 1-0 Olimpia Asunción
| 01.10.2015 | Olimpia Asunción | 0-0 | Independiente | |
| 24.09.2015 | Independiente | 1-0 | Olimpia Asunción | |
*River Plate 2-1 LDU Quito
| 01.10.2015 | LDU Quito | 1-0 | River Plate | |
| 24.09.2015 | River Plate | 2-0 | LDU Quito | |