*Arsenal FC 1-1 AS Roma
| 11.03.2009 | AS Roma | 1-0/p.6-7 | Arsenal FC | |
| 24.02.2009 | Arsenal FC | 1-0 | AS Roma | |
Atlético Madrid 2-2 FC Porto *
| 11.03.2009 | FC Porto | 0-0 | Atlético Madrid | |
| 24.02.2009 | Atlético Madrid | 2-2 | FC Porto | |
*Chelsea FC 3-2 Juventus FC
| 10.03.2009 | Juventus FC | 2-2 | Chelsea FC | |
| 25.02.2009 | Chelsea FC | 1-0 | Juventus FC | |
Inter Milan 0-2 Manchester United *
| 11.03.2009 | Manchester United | 2-0 | Inter Milan | |
| 24.02.2009 | Inter Milan | 0-0 | Manchester United | |
Lyon 3-6 FC Barcelona *
| 11.03.2009 | FC Barcelona | 5-2 | Lyon | |
| 24.02.2009 | Lyon | 1-1 | FC Barcelona | |
*Villarreal CF 3-2 Panathinaikos
| 10.03.2009 | Panathinaikos | 1-2 | Villarreal CF | |
| 25.02.2009 | Villarreal CF | 1-1 | Panathinaikos | |
Real Madrid 0-5 Liverpool *
| 10.03.2009 | Liverpool | 4-0 | Real Madrid | |
| 25.02.2009 | Real Madrid | 0-1 | Liverpool | |
Sporting Lisboa 1-12 Bayern München *
| 10.03.2009 | Bayern München | 7-1 | Sporting Lisboa | |
| 25.02.2009 | Sporting Lisboa | 0-5 | Bayern München | |