*Dinamo Zagreb 3-0 Omonia Nicosia
| 27.07.2021 | Omonia Nicosia | 0-1 | Dinamo Zagreb | |
| 20.07.2021 | Dinamo Zagreb | 2-0 | Omonia Nicosia | |
*Ferencvaros TC 5-1 VMFD Zalgiris
| 27.07.2021 | VMFD Zalgiris | 1-3 | Ferencvaros TC | |
| 20.07.2021 | Ferencvaros TC | 2-0 | VMFD Zalgiris | |
Kairat Almaty 2-6 FK Crvena Zvezda *
| 28.07.2021 | FK Crvena Zvezda | 5-0 | Kairat Almaty | |
| 21.07.2021 | Kairat Almaty | 2-1 | FK Crvena Zvezda | |
*Malmö FF 4-3 HJK Helsinki
| 27.07.2021 | HJK Helsinki | 2-2 | Malmö FF | |
| 21.07.2021 | Malmö FF | 2-1 | HJK Helsinki | |
*Legia Warszawa 3-1 Flora Tallinn
| 27.07.2021 | Flora Tallinn | 0-1 | Legia Warszawa | |
| 21.07.2021 | Legia Warszawa | 2-1 | Flora Tallinn | |
Lincoln Red Imps 1-4 CFR Cluj *
| 28.07.2021 | CFR Cluj | 2-0 | Lincoln Red Imps | |
| 20.07.2021 | Lincoln Red Imps | 1-2 | CFR Cluj | |
Mura 1-3 Ludogorets *
| 28.07.2021 | Ludogorets | 3-1 | Mura | |
| 21.07.2021 | Mura | 0-0 | Ludogorets | |
*Olympiakos Pireus 2-0 Neftchi Baku
| 28.07.2021 | Neftchi Baku | 0-1 | Olympiakos Pireus | |
| 21.07.2021 | Olympiakos Pireus | 1-0 | Neftchi Baku | |
Alashkert Martuni 1-4 Sheriff Tiraspol *
| 28.07.2021 | Sheriff Tiraspol | 3-1 | Alashkert Martuni | |
| 20.07.2021 | Alashkert Martuni | 0-1 | Sheriff Tiraspol | |
Slovan Bratislava 2-3 BSC Young Boys *
| 28.07.2021 | BSC Young Boys | 3-2 | Slovan Bratislava | |
| 21.07.2021 | Slovan Bratislava | 0-0 | BSC Young Boys | |