Anderlecht 4-5 Vitesse Arnhem *
| 26.08.2021 | Vitesse Arnhem | 2-1 | Anderlecht | |
| 19.08.2021 | Anderlecht | 3-3 | Vitesse Arnhem | |
Trabzonspor 1-5 AS Roma *
| 26.08.2021 | AS Roma | 3-0 | Trabzonspor | |
| 19.08.2021 | Trabzonspor | 1-2 | AS Roma | |
CD Santa Clara 2-3 FK Partizan *
| 26.08.2021 | FK Partizan | 2-0 | CD Santa Clara | |
| 19.08.2021 | CD Santa Clara | 2-1 | FK Partizan | |
Viktoria Plzen 2-3 CSKA Sofia *
| 26.08.2021 | CSKA Sofia | 3-0 AET | Viktoria Plzen | |
| 19.08.2021 | Viktoria Plzen | 2-0 | CSKA Sofia | |
*FC Basel 4-4 Hammarby IF
| 26.08.2021 | Hammarby IF | 3-1/p.3-4 | FC Basel | |
| 19.08.2021 | FC Basel | 3-1 | Hammarby IF | |
Hapoel Be'er Sheva 1-3 Anorthosis FC *
| 26.08.2021 | Anorthosis FC | 3-1 | Hapoel Be'er Sheva | |
| 19.08.2021 | Hapoel Be'er Sheva | 0-0 | Anorthosis FC | |
*PAOK Salonica 3-1 HNK Rijeka
| 26.08.2021 | HNK Rijeka | 0-2 | PAOK Salonica | |
| 19.08.2021 | PAOK Salonica | 1-1 | HNK Rijeka | |
*Feyenoord 6-3 IF Elfsborg
| 26.08.2021 | IF Elfsborg | 3-1 | Feyenoord | |
| 19.08.2021 | Feyenoord | 5-0 | IF Elfsborg | |
KuPS Kuopio 0-4 Union Berlin *
| 26.08.2021 | Union Berlin | 0-0 | KuPS Kuopio | |
| 19.08.2021 | KuPS Kuopio | 0-4 | Union Berlin | |
*LASK Linz 3-1 St Johnstone
| 26.08.2021 | St Johnstone | 0-2 | LASK Linz | |
| 19.08.2021 | LASK Linz | 1-1 | St Johnstone | |
*FK Jablonec 8-1 MSK Zilina
| 26.08.2021 | MSK Zilina | 0-3 | FK Jablonec | |
| 19.08.2021 | FK Jablonec | 5-1 | MSK Zilina | |
*Qarabag FK 4-1 Aberdeen FC
| 26.08.2021 | Aberdeen FC | 1-3 | Qarabag FK | |
| 19.08.2021 | Qarabag FK | 1-0 | Aberdeen FC | |
*Stade Rennais 5-1 Rosenborg BK
| 26.08.2021 | Rosenborg BK | 1-3 | Stade Rennais | |
| 19.08.2021 | Stade Rennais | 2-0 | Rosenborg BK | |
Shakhtyor Karagandy 1-4 Maccabi Tel Aviv *
| 26.08.2021 | Maccabi Tel Aviv | 2-0 | Shakhtyor Karagandy | |
| 19.08.2021 | Shakhtyor Karagandy | 1-2 | Maccabi Tel Aviv | |
Sivasspor 1-7 FC København *
| 26.08.2021 | FC København | 5-0 | Sivasspor | |
| 19.08.2021 | Sivasspor | 1-2 | FC København | |
Paços de Ferreira 1-3 Tottenham *
| 26.08.2021 | Tottenham | 3-0 | Paços de Ferreira | |
| 19.08.2021 | Paços de Ferreira | 1-0 | Tottenham | |