Alashkert Martuni 2-4 Hamrun Spartans *
| 14.07.2022 | Hamrun Spartans | 4-1 | Alashkert Martuni | |
| 07.07.2022 | Alashkert Martuni | 1-0 | Hamrun Spartans | |
*Shkendija'79 4-2 Ararat Yerevan
| 14.07.2022 | Ararat Yerevan | 2-2 | Shkendija'79 | |
| 07.07.2022 | Shkendija'79 | 2-0 | Ararat Yerevan | |
Borac Banja Luka 3-3 B36 Torshavn *
| 14.07.2022 | B36 Torshavn | 3-1/p.4-3 | Borac Banja Luka | |
| 07.07.2022 | Borac Banja Luka | 2-0 | B36 Torshavn | |
UE Santa Coloma 1-5 Breidablik *
| 14.07.2022 | Breidablik | 4-1 | UE Santa Coloma | |
| 07.07.2022 | UE Santa Coloma | 0-1 | Breidablik | |
FCB Magpies 3-4 Crusaders Belfast *
| 14.07.2022 | Crusaders Belfast | 3-1 | FCB Magpies | |
| 07.07.2022 | FCB Magpies | 2-1 | Crusaders Belfast | |
*Dinamo Minsk 3-2 Decic Tuzi
| 14.07.2022 | Decic Tuzi | 1-2 | Dinamo Minsk | |
| 07.07.2022 | Dinamo Minsk | 1-1 | Decic Tuzi | |
Dinamo Tbilisi 4-4 Paide Linnameeskond *
| 14.07.2022 | Paide Linnameeskond | 1-2/p.6-5 | Dinamo Tbilisi | |
| 07.07.2022 | Dinamo Tbilisi | 2-3 | Paide Linnameeskond | |
*Dunajska Streda 5-1 Cliftonville Belfast
| 14.07.2022 | Cliftonville Belfast | 0-3 | Dunajska Streda | |
| 07.07.2022 | Dunajska Streda | 2-1 | Cliftonville Belfast | |
*Vikingur Gota 3-1 Europa FC
| 14.07.2022 | Europa FC | 1-2 | Vikingur Gota | |
| 06.07.2022 | Vikingur Gota | 1-0 | Europa FC | |
*FK Buducnost 4-2 Llapi
| 14.07.2022 | Llapi | 2-2 | FK Buducnost | |
| 07.07.2022 | FK Buducnost | 2-0 | Llapi | |
FK Panevezys 0-2 FC Milsami *
| 14.07.2022 | FC Milsami | 2-0 | FK Panevezys | |
| 07.07.2022 | FK Panevezys | 0-0 | FC Milsami | |
SP Tre Penne 0-8 FK Tuzla City *
| 14.07.2022 | FK Tuzla City | 6-0 | SP Tre Penne | |
| 07.07.2022 | SP Tre Penne | 0-2 | FK Tuzla City | |
Flora Tallinn 3-4 Seinajoen JK *
| 14.07.2022 | Seinajoen JK | 4-2 AET | Flora Tallinn | |
| 07.07.2022 | Flora Tallinn | 1-0 | Seinajoen JK | |
Gjilani 2-3 FK Liepaja *
| 14.07.2022 | FK Liepaja | 3-1 | Gjilani | |
| 07.07.2022 | Gjilani | 1-0 | FK Liepaja | |
*Gzira United 2-1 AC d'Escaldes
| 14.07.2022 | AC d'Escaldes | 0-1 AET | Gzira United | |
| 05.07.2022 | Gzira United | 1-1 | AC d'Escaldes | |
Inter Turku 1-3 Drita FC *
| 12.07.2022 | Drita FC | 3-0 | Inter Turku | |
| 06.07.2022 | Inter Turku | 1-0 | Drita FC | |
*KF Laci 1-0 Iskra Danilovgrad
| 14.07.2022 | Iskra Danilovgrad | 0-1 | KF Laci | |
| 07.07.2022 | KF Laci | 0-0 | Iskra Danilovgrad | |
*Pogoń Szczecin 4-2 KR Reykjavik
| 14.07.2022 | KR Reykjavik | 1-0 | Pogoń Szczecin | |
| 07.07.2022 | Pogoń Szczecin | 4-1 | KR Reykjavik | |
*KuPS Kuopio 2-0 Dila Gori
| 14.07.2022 | Dila Gori | 0-0 | KuPS Kuopio | |
| 07.07.2022 | KuPS Kuopio | 2-0 | Dila Gori | |
*Lechia Gdansk 6-2 Akademija Pandev
| 14.07.2022 | Akademija Pandev | 1-2 | Lechia Gdansk | |
| 07.07.2022 | Lechia Gdansk | 4-1 | Akademija Pandev | |
*MFK Ruzomberok 2-0 FK Kauno Zalgiris
| 14.07.2022 | FK Kauno Zalgiris | 0-0 | MFK Ruzomberok | |
| 07.07.2022 | MFK Ruzomberok | 2-0 | FK Kauno Zalgiris | |
Sfîntul Gheorghe 2-4 Mura *
| 14.07.2022 | Mura | 2-1 | Sfîntul Gheorghe | |
| 07.07.2022 | Sfîntul Gheorghe | 1-2 | Mura | |
HB Torshavn 2-2 Newtown AFC *
| 14.07.2022 | Newtown AFC | 2-1/p.4-2 | HB Torshavn | |
| 07.07.2022 | HB Torshavn | 1-0 | Newtown AFC | |
*Olimpija Ljubljana 3-2 Differdange
| 14.07.2022 | Differdange | 1-2 AET | Olimpija Ljubljana | |
| 07.07.2022 | Olimpija Ljubljana | 1-1 | Differdange | |
*FC Iberia 1999 1-1 Partizani Tirana
| 14.07.2022 | Partizani Tirana | 0-1/p.4-5 | FC Iberia 1999 | |
| 07.07.2022 | FC Iberia 1999 | 0-1 | Partizani Tirana | |
Floriana FC 0-1 Petrocub Hîncești *
| 14.07.2022 | Petrocub Hîncești | 1-0 | Floriana FC | |
| 07.07.2022 | Floriana FC | 0-0 | Petrocub Hîncești | |
Derry City 0-4 Riga FC *
| 14.07.2022 | Riga FC | 2-0 | Derry City | |
| 07.07.2022 | Derry City | 0-2 | Riga FC | |
Bala Town 2-2 Sligo Rovers *
| 14.07.2022 | Sligo Rovers | 0-1/p.4-3 | Bala Town | |
| 07.07.2022 | Bala Town | 1-2 | Sligo Rovers | |
CS Fola Esch 1-4 SP Tre Fiori *
| 14.07.2022 | SP Tre Fiori | 3-1 | CS Fola Esch | |
| 07.07.2022 | CS Fola Esch | 0-1 | SP Tre Fiori | |
*St Joseph's (GIB) 1-0 Larne FC
| 14.07.2022 | Larne FC | 0-1 | St Joseph's (GIB) | |
| 05.07.2022 | St Joseph's (GIB) | 0-0 | Larne FC | |