BATE Borisov 1-3 Arsenal FC *
| 21.02.2019 | Arsenal FC | 3-0 | BATE Borisov | |
| 14.02.2019 | BATE Borisov | 1-0 | Arsenal FC | |
Malmö FF 1-5 Chelsea FC *
| 21.02.2019 | Chelsea FC | 3-0 | Malmö FF | |
| 14.02.2019 | Malmö FF | 1-2 | Chelsea FC | |
Viktoria Plzen 2-4 Dinamo Zagreb *
| 21.02.2019 | Dinamo Zagreb | 3-0 | Viktoria Plzen | |
| 14.02.2019 | Viktoria Plzen | 2-1 | Dinamo Zagreb | |
Olympiakos Pireus 2-3 Dynamo Kyiv *
| 21.02.2019 | Dynamo Kyiv | 1-0 | Olympiakos Pireus | |
| 14.02.2019 | Olympiakos Pireus | 2-2 | Dynamo Kyiv | |
Fenerbahçe SK 2-3 Zenit *
| 21.02.2019 | Zenit | 3-1 | Fenerbahçe SK | |
| 12.02.2019 | Fenerbahçe SK | 1-0 | Zenit | |
*FK Krasnodar 1-1 Bayer Leverkusen
| 21.02.2019 | Bayer Leverkusen | 1-1 | FK Krasnodar | |
| 14.02.2019 | FK Krasnodar | 0-0 | Bayer Leverkusen | |
Galatasaray SK 1-2 SL Benfica *
| 21.02.2019 | SL Benfica | 0-0 | Galatasaray SK | |
| 14.02.2019 | Galatasaray SK | 1-2 | SL Benfica | |
*Slavia Praha 4-1 Racing Genk
| 21.02.2019 | Racing Genk | 1-4 | Slavia Praha | |
| 14.02.2019 | Slavia Praha | 0-0 | Racing Genk | |
Rapid Wien 0-5 Inter Milan *
| 21.02.2019 | Inter Milan | 4-0 | Rapid Wien | |
| 14.02.2019 | Rapid Wien | 0-1 | Inter Milan | |
Club Brugge 2-5 RB Salzburg *
| 21.02.2019 | RB Salzburg | 4-0 | Club Brugge | |
| 14.02.2019 | Club Brugge | 2-1 | RB Salzburg | |
*Stade Rennais 6-4 Real Betis
| 21.02.2019 | Real Betis | 1-3 | Stade Rennais | |
| 14.02.2019 | Stade Rennais | 3-3 | Real Betis | |
Lazio 0-3 Sevilla FC *
| 20.02.2019 | Sevilla FC | 2-0 | Lazio | |
| 14.02.2019 | Lazio | 0-1 | Sevilla FC | |
Shakhtar Donetsk 3-6 Eintracht Frankfurt *
| 21.02.2019 | Eintracht Frankfurt | 4-1 | Shakhtar Donetsk | |
| 14.02.2019 | Shakhtar Donetsk | 2-2 | Eintracht Frankfurt | |
FC Zürich 1-5 SSC Napoli *
| 21.02.2019 | SSC Napoli | 2-0 | FC Zürich | |
| 14.02.2019 | FC Zürich | 1-3 | SSC Napoli | |
Celtic FC 0-3 Valencia CF *
| 21.02.2019 | Valencia CF | 1-0 | Celtic FC | |
| 14.02.2019 | Celtic FC | 0-2 | Valencia CF | |
Sporting Lisboa 1-2 Villarreal CF *
| 21.02.2019 | Villarreal CF | 1-1 | Sporting Lisboa | |
| 14.02.2019 | Sporting Lisboa | 0-1 | Villarreal CF | |