Kairat Almaty 2-3 Alashkert Martuni *
| 12.08.2021 | Alashkert Martuni | 3-2 AET | Kairat Almaty | |
| 05.08.2021 | Kairat Almaty | 0-0 | Alashkert Martuni | |
*Omonia Nicosia 2-2 Flora Tallinn
| 10.08.2021 | Flora Tallinn | 2-1/p.4-5 | Omonia Nicosia | |
| 05.08.2021 | Omonia Nicosia | 1-0 | Flora Tallinn | |
Lincoln Red Imps 2-4 Slovan Bratislava *
| 10.08.2021 | Slovan Bratislava | 1-1 | Lincoln Red Imps | |
| 05.08.2021 | Lincoln Red Imps | 1-3 | Slovan Bratislava | |
Neftchi Baku 2-5 HJK Helsinki *
| 12.08.2021 | HJK Helsinki | 3-0 | Neftchi Baku | |
| 03.08.2021 | Neftchi Baku | 2-2 | HJK Helsinki | |
*Mura 1-0 VMFD Zalgiris
| 12.08.2021 | VMFD Zalgiris | 0-1 | Mura | |
| 05.08.2021 | Mura | 0-0 | VMFD Zalgiris | |