Paris St. Germain 0-3 Dynamo Kyiv *
| 16.04.2009 | Dynamo Kyiv | 3-0 | Paris St. Germain | |
| 09.04.2009 | Paris St. Germain | 0-0 | Dynamo Kyiv | |
*Hamburger SV 4-3 Manchester City
| 16.04.2009 | Manchester City | 2-1 | Hamburger SV | |
| 09.04.2009 | Hamburger SV | 3-1 | Manchester City | |
*Shakhtar Donetsk 4-1 Olympique Marseille
| 16.04.2009 | Olympique Marseille | 1-2 | Shakhtar Donetsk | |
| 09.04.2009 | Shakhtar Donetsk | 2-0 | Olympique Marseille | |
*Werder Bremen 6-4 Udinese Calcio
| 16.04.2009 | Udinese Calcio | 3-3 | Werder Bremen | |
| 09.04.2009 | Werder Bremen | 3-1 | Udinese Calcio | |