Brasiliense/DF 1-1 Nova Mutum/MT *
| 03.11.2021 | Nova Mutum/MT | 1-0/p.3-2 | Brasiliense/DF | |
| 28.10.2021 | Brasiliense/DF | 1-0 | Nova Mutum/MT | |
*Paysandu/PA 4-2 Castanhal/PA
| 10.11.2021 | Castanhal/PA | 1-3 | Paysandu/PA | |
| 28.10.2021 | Paysandu/PA | 1-1 | Castanhal/PA | |
Manaus FC/AM 1-4 Remo/PA *
| 25.11.2021 | Remo/PA | 3-0 | Manaus FC/AM | |
| 12.11.2021 | Manaus FC/AM | 1-1 | Remo/PA | |
Aquidauanense/MS 0-8 Vila Nova/GO *
| 04.11.2021 | Vila Nova/GO | 7-0 | Aquidauanense/MS | |
| 28.10.2021 | Aquidauanense/MS | 0-1 | Vila Nova/GO | |