Puerto Montt 2-3 Deportes Copiapó *
| 01.12.2021 | Deportes Copiapó | 2-2 | Puerto Montt | |
| 26.11.2021 | Puerto Montt | 0-1 | Deportes Copiapó | |
Santiago Morning 2-3 Deportes Temuco *
| 02.12.2021 | Deportes Temuco | 2-1 | Santiago Morning | |
| 25.11.2021 | Santiago Morning | 1-1 | Deportes Temuco | |