*Colorado Rapids 2-2 Columbus Crew
| 06.11.2010 | Columbus Crew | 2-1/p.4-5 | Colorado Rapids | |
| 29.10.2010 | Colorado Rapids | 1-0 | Columbus Crew | |
*FC Dallas 3-2 Real Salt Lake
| 07.11.2010 | Real Salt Lake | 1-1 | FC Dallas | |
| 30.10.2010 | FC Dallas | 2-1 | Real Salt Lake | |
*San Jose Earthquakes 3-2 New York Red Bulls
| 05.11.2010 | New York Red Bulls | 1-3 | San Jose Earthquakes | |
| 31.10.2010 | San Jose Earthquakes | 0-1 | New York Red Bulls | |
Seattle Sounders 1-3 Los Angeles Galaxy *
| 08.11.2010 | Los Angeles Galaxy | 2-1 | Seattle Sounders | |
| 01.11.2010 | Seattle Sounders | 0-1 | Los Angeles Galaxy | |