Columbus Crew 1-3 New York Red Bulls *
| 12.11.2018 | New York Red Bulls | 3-0 | Columbus Crew | |
| 04.11.2018 | Columbus Crew | 1-0 | New York Red Bulls | |
New York City FC 1-4 Atlanta United *
| 11.11.2018 | Atlanta United | 3-1 | New York City FC | |
| 05.11.2018 | New York City FC | 0-1 | Atlanta United | |
*Portland Timbers 4-4 Seattle Sounders
| 09.11.2018 | Seattle Sounders | 3-2/p.2-4 | Portland Timbers | |
| 04.11.2018 | Portland Timbers | 2-1 | Seattle Sounders | |
Real Salt Lake 3-5 Sporting Kansas City *
| 11.11.2018 | Sporting Kansas City | 4-2 | Real Salt Lake | |
| 05.11.2018 | Real Salt Lake | 1-1 | Sporting Kansas City | |