*Los Angeles FC 6-2 Austin FC
| 03.11.2025 | Austin FC | 1-4 | Los Angeles FC | |
| 30.10.2025 | Los Angeles FC | 2-1 | Austin FC | |
Charlotte FC 0-1 New York City FC
| 08.11.2025 | Charlotte FC | - | New York City FC | |
| 01.11.2025 | New York City FC | 0-0/p.6-7 | Charlotte FC | |
| 28.10.2025 | Charlotte FC | 0-1 | New York City FC | |
FC Cincinnati 1-4 Columbus Crew
| 09.11.2025 | FC Cincinnati | - | Columbus Crew | |
| 03.11.2025 | Columbus Crew | 4-0 | FC Cincinnati | |
| 27.10.2025 | FC Cincinnati | 1-0 | Columbus Crew | |
*Vancouver WC 4-1 FC Dallas
| 02.11.2025 | FC Dallas | 1-1/p.2-4 | Vancouver WC | |
| 27.10.2025 | Vancouver WC | 3-0 | FC Dallas | |
Inter Miami CF 4-3 Nashville SC
| 09.11.2025 | Inter Miami CF | - | Nashville SC | |
| 02.11.2025 | Nashville SC | 2-1 | Inter Miami CF | |
| 25.10.2025 | Inter Miami CF | 3-1 | Nashville SC | |
*Philadelphia Union 5-2 Chicago Fire
| 01.11.2025 | Chicago Fire | 0-3 | Philadelphia Union | |
| 26.10.2025 | Philadelphia Union | 2-2/p.4-2 | Chicago Fire | |
San Diego FC 4-3 Portland Timbers
| 10.11.2025 | San Diego FC | - | Portland Timbers | |
| 02.11.2025 | Portland Timbers | 2-2/p.3-2 | San Diego FC | |
| 27.10.2025 | San Diego FC | 2-1 | Portland Timbers | |
Minnesota United 2-4 Seattle Sounders
| 09.11.2025 | Minnesota United | - | Seattle Sounders | |
| 04.11.2025 | Seattle Sounders | 4-2 | Minnesota United | |
| 28.10.2025 | Minnesota United | 0-0/p.3-2 | Seattle Sounders | |