Malindi SC 2-7 Al Masry *
| 29.09.2019 | Al Masry | 3-1 | Malindi SC | |
| 15.09.2019 | Malindi SC | 1-4 | Al Masry | |
AS Kigali 2-3 Proline FC *
| 28.09.2019 | Proline FC | 2-1 | AS Kigali | |
| 14.09.2019 | AS Kigali | 1-1 | Proline FC | |
AS Pélican 3-4 Enugu Rangers *
| 29.09.2019 | Enugu Rangers | 3-1 | AS Pélican | |
| 14.09.2019 | AS Pélican | 2-1 | Enugu Rangers | |
Young Buffaloes 1-3 Bidvest Wits *
| 27.09.2019 | Bidvest Wits | 3-0 | Young Buffaloes | |
| 14.09.2019 | Young Buffaloes | 1-0 | Bidvest Wits | |
*Pyramids FC 2-1 CR Belouizdad
| 29.09.2019 | CR Belouizdad | 0-1 | Pyramids FC | |
| 14.09.2019 | Pyramids FC | 1-1 | CR Belouizdad | |
Maranatha FC 2-3 Djoliba AC *
| 29.09.2019 | Djoliba AC | 1-1 | Maranatha FC | |
| 14.09.2019 | Maranatha FC | 1-2 | Djoliba AC | |
Santoba FC 0-3 FC San Pédro *
| 29.09.2019 | FC San Pédro | 3-0 | Santoba FC | |
| 15.09.2019 | Santoba FC | 0-0 | FC San Pédro | |
Ittihad Tripoli 1-1 Hassania Agadir *
| 28.09.2019 | Hassania Agadir | 0-0 | Ittihad Tripoli | |
| 14.09.2019 | Ittihad Tripoli | 1-1 | Hassania Agadir | |
Khartoum Al Watani 3-3 DC Motema Pembe *
| 27.09.2019 | DC Motema Pembe | 1-2/p.3-1 | Khartoum Al Watani | |
| 13.09.2019 | Khartoum Al Watani | 1-2 | DC Motema Pembe | |
*Paradou AC 3-1 CS Sfaxien
| 29.09.2019 | CS Sfaxien | 0-0 | Paradou AC | |
| 15.09.2019 | Paradou AC | 3-1 | CS Sfaxien | |
Ashanti Gold SC 3-4 Renaissance Berkane *
| 28.09.2019 | Renaissance Berkane | 2-0 | Ashanti Gold SC | |
| 14.09.2019 | Ashanti Gold SC | 3-2 | Renaissance Berkane | |
*ESAE FC 0-0 Salitas FC
| 28.09.2019 | Salitas FC | 0-0/p.2-3 | ESAE FC | |
| 15.09.2019 | ESAE FC | 0-0 | Salitas FC | |
Azam FC 0-2 Triangle United FC *
| 28.09.2019 | Triangle United FC | 1-0 | Azam FC | |
| 15.09.2019 | Azam FC | 0-1 | Triangle United FC | |
*TS Galaxy FC 4-1 CNaPS Sport
| 28.09.2019 | CNaPS Sport | 1-3 | TS Galaxy FC | |
| 15.09.2019 | TS Galaxy FC | 1-0 | CNaPS Sport | |
*Bandari FC 3-2 US Ben Guerdane
| 29.09.2019 | US Ben Guerdane | 2-1 | Bandari FC | |
| 14.09.2019 | Bandari FC | 2-0 | US Ben Guerdane | |
Bolton City YC (MRI) 1-5 Zanaco FC *
| 28.09.2019 | Zanaco FC | 3-0 | Bolton City YC (MRI) | |
| 15.09.2019 | Bolton City YC (MRI) | 1-2 | Zanaco FC | |