AS Génération Foot 1-1 ESAE FC *
| 05.11.2019 | ESAE FC | 0-1/p.4-3 | AS Génération Foot | |
| 30.10.2019 | AS Génération Foot | 0-1 | ESAE FC | |
Asante Kotoko 1-2 FC San Pédro *
| 03.11.2019 | FC San Pédro | 2-0 | Asante Kotoko | |
| 27.10.2019 | Asante Kotoko | 1-0 | FC San Pédro | |
ASC Kara 2-2 Enugu Rangers *
| 03.11.2019 | Enugu Rangers | 1-0 | ASC Kara | |
| 27.10.2019 | ASC Kara | 2-1 | Enugu Rangers | |
Cano Sport 2-8 Zanaco FC *
| 03.11.2019 | Zanaco FC | 5-1 | Cano Sport | |
| 27.10.2019 | Cano Sport | 1-3 | Zanaco FC | |
Côte d'Or FC 0-6 Al Masry *
| 03.11.2019 | Al Masry | 2-0 | Côte d'Or FC | |
| 27.10.2019 | Côte d'Or FC | 0-4 | Al Masry | |
Elect Sport FC 0-5 Djoliba AC *
| 03.11.2019 | Djoliba AC | 4-0 | Elect Sport FC | |
| 27.10.2019 | Elect Sport FC | 0-1 | Djoliba AC | |
*Enyimba 4-1 TS Galaxy FC
| 03.11.2019 | TS Galaxy FC | 1-2 | Enyimba | |
| 27.10.2019 | Enyimba | 2-0 | TS Galaxy FC | |
*FC Nouadhibou 4-3 Triangle United FC
| 03.11.2019 | Triangle United FC | 3-2 | FC Nouadhibou | |
| 27.10.2019 | FC Nouadhibou | 2-0 | Triangle United FC | |
Fosa Juniors 2-5 Renaissance Berkane *
| 03.11.2019 | Renaissance Berkane | 5-0 | Fosa Juniors | |
| 27.10.2019 | Fosa Juniors | 2-0 | Renaissance Berkane | |
Gor Mahia 2-3 DC Motema Pembe *
| 03.11.2019 | DC Motema Pembe | 2-1 | Gor Mahia | |
| 27.10.2019 | Gor Mahia | 1-1 | DC Motema Pembe | |
Green Eagles 2-3 Hassania Agadir *
| 03.11.2019 | Hassania Agadir | 2-1 | Green Eagles | |
| 27.10.2019 | Green Eagles | 1-1 | Hassania Agadir | |
*Horoya AC 5-2 Bandari FC
| 03.11.2019 | Bandari FC | 0-1 | Horoya AC | |
| 27.10.2019 | Horoya AC | 4-2 | Bandari FC | |
KCCA FC 1-4 Paradou AC *
| 03.11.2019 | Paradou AC | 4-1 | KCCA FC | |
| 27.10.2019 | KCCA FC | 0-0 | Paradou AC | |
*Nasr Benghazi 4-2 Proline FC
| 03.11.2019 | Proline FC | 0-2 | Nasr Benghazi | |
| 27.10.2019 | Nasr Benghazi | 2-2 | Proline FC | |
UD Songo 1-8 Bidvest Wits *
| 03.11.2019 | Bidvest Wits | 6-0 | UD Songo | |
| 27.10.2019 | UD Songo | 1-2 | Bidvest Wits | |
Young Africans 1-5 Pyramids FC *
| 03.11.2019 | Pyramids FC | 3-0 | Young Africans | |
| 27.10.2019 | Young Africans | 1-2 | Pyramids FC | |