Côte d'Or FC 1-5 Stade d'Abidjan *
| 16.09.2025 | Côte d'Or FC | 0-2 | Stade d'Abidjan | |
| 24.09.2025 | Stade d'Abidjan | 3-1 | Côte d'Or FC | |
Dadje FC 0-1 Al Ahli Tripoli *
| 19.09.2025 | Dadje FC | 0-0 | Al Ahli Tripoli | |
| 28.09.2025 | Al Ahli Tripoli | 1-0 | Dadje FC | |
Wiliete SC 0-5 Young Africans SC *
| 19.09.2025 | Wiliete SC | 0-3 | Young Africans SC | |
| 27.09.2025 | Young Africans SC | 2-0 | Wiliete SC | |
African Stars FC 0-2 Vipers SC *
| 19.09.2025 | African Stars FC | 0-1 | Vipers SC | |
| 27.09.2025 | Vipers SC | 1-0 | African Stars FC | |
*Ethiopian Insurance 4-3 Mlandege FC
| 20.09.2025 | Ethiopian Insurance | 2-0 | Mlandege FC | |
| 27.09.2025 | Mlandege FC | 3-2 | Ethiopian Insurance | |
*Power Dynamos 1-1 ASEC Mimosas
| 20.09.2025 | Power Dynamos | 1-0 | ASEC Mimosas | |
| 28.09.2025 | ASEC Mimosas | 1-0/p.4-5 | Power Dynamos | |
Lioli FC 0-7 Orlando Pirates *
| 20.09.2025 | Lioli FC | 0-3 | Orlando Pirates | |
| 27.09.2025 | Orlando Pirates | 4-0 | Lioli FC | |
Mogadishu City 3-3 Kenya Police FC *
| 20.09.2025 | Mogadishu City | 1-3 | Kenya Police FC | |
| 28.09.2025 | Kenya Police FC | 0-2 | Mogadishu City | |
Cercle de Joachim 0-6 Petro Atlético Luanda *
| 20.09.2025 | Cercle de Joachim | 0-3 | Petro Atlético Luanda | |
| 27.09.2025 | Petro Atlético Luanda | 3-0 | Cercle de Joachim | |
Aigles du Congo 0-1 Rivers United *
| 20.09.2025 | Aigles du Congo | 0-0 | Rivers United | |
| 28.09.2025 | Rivers United | 1-0 | Aigles du Congo | |
Bibiani Gold Stars FC 0-7 JS Kabylie *
| 20.09.2025 | Bibiani Gold Stars FC | 0-2 | JS Kabylie | |
| 28.09.2025 | JS Kabylie | 5-0 | Bibiani Gold Stars FC | |
FC Fassell 0-3 MC Alger *
| 20.09.2025 | FC Fassell | 0-0 | MC Alger | |
| 27.09.2025 | MC Alger | 3-0 | FC Fassell | |
*Rahimo FC 0-0 AS Mangasport
| 20.09.2025 | Rahimo FC | 0-0 | AS Mangasport | |
| 28.09.2025 | AS Mangasport | 0-0/p.2-4 | Rahimo FC | |
Gaborone United 1-2 Simba SC *
| 20.09.2025 | Gaborone United | 0-1 | Simba SC | |
| 28.09.2025 | Simba SC | 1-1 | Gaborone United | |
Al Hilal Benghazi 1-2 Horoya AC *
| 20.09.2025 | Al Hilal Benghazi | 1-0 | Horoya AC | |
| 27.09.2025 | Horoya AC | 2-0 | Al Hilal Benghazi | |
ASSM Elgeco Plus 1-1 Silver Strikers *
| 21.09.2025 | ASSM Elgeco Plus | 1-1 | Silver Strikers | |
| 27.09.2025 | Silver Strikers | 0-0 | ASSM Elgeco Plus | |
Jamus FC 0-1 Al Hilal Omdurman *
| 21.09.2025 | Jamus FC | 0-0 | Al Hilal Omdurman | |
| 28.09.2025 | Al Hilal Omdurman | 1-0 | Jamus FC | |
*Aigle Noir 1-1 ASAS Djibouti Télécom
| 21.09.2025 | Aigle Noir | 0-0 | ASAS Djibouti Télécom | |
| 27.09.2025 | ASAS Djibouti Télécom | 1-1 | Aigle Noir | |
*Colombe FC 1-0 ASC Jaraaf
| 21.09.2025 | Colombe FC | 0-0 | ASC Jaraaf | |
| 28.09.2025 | ASC Jaraaf | 0-1 | Colombe FC | |
AS Tempête Mocaf 0-7 Stade Malien *
| 21.09.2025 | AS Tempête Mocaf | 0-5 | Stade Malien | |
| 27.09.2025 | Stade Malien | 2-0 | AS Tempête Mocaf | |
Fundación Bata 0-2 FC Nouadhibou *
| 21.09.2025 | Fundación Bata | 0-0 | FC Nouadhibou | |
| 28.09.2025 | FC Nouadhibou | 2-0 | Fundación Bata | |
AC Léopard 0-0 Black Bulls *
| 21.09.2025 | AC Léopard | 0-0 | Black Bulls | |
| 27.09.2025 | Black Bulls | 0-0/p.5-4 | AC Léopard | |
ASFAN Niamey 1-7 Esperance ST *
| 21.09.2025 | ASFAN Niamey | 0-3 | Esperance ST | |
| 27.09.2025 | Esperance ST | 4-1 | ASFAN Niamey | |
East End Lions FC 1-7 US Monastir *
| 21.09.2025 | East End Lions FC | 0-4 | US Monastir | |
| 28.09.2025 | US Monastir | 3-1 | East End Lions FC | |
*Remo Stars 5-0 US Zilimadjou
| 21.09.2025 | Remo Stars | 4-0 | US Zilimadjou | |
| 26.09.2025 | US Zilimadjou | 0-1 | Remo Stars | |
ASC Kara 2-4 Renaissance Berkane *
| 21.09.2025 | ASC Kara | 1-1 | Renaissance Berkane | |
| 27.09.2025 | Renaissance Berkane | 3-1 | ASC Kara | |
Simba Bhora FC (ZIM) 1-1 Nsingizini Hotspurs FC *
| 21.09.2025 | Simba Bhora FC (ZIM) | 1-0 | Nsingizini Hotspurs FC | |
| 28.09.2025 | Nsingizini Hotspurs FC | 1-0/p.4-2 | Simba Bhora FC (ZIM) | |
Real de Banjul 1-4 FAR Rabat *
| 21.09.2025 | Real de Banjul | 0-2 | FAR Rabat | |
| 27.09.2025 | FAR Rabat | 2-1 | Real de Banjul | |
*Saint Eloi Lupopo 1-0 Al Merreikh SC
| 27.09.2025 | Saint Eloi Lupopo | 1-0 | Al Merreikh SC | |
| 04.10.2025 | Al Merreikh SC | 0-0 | Saint Eloi Lupopo | |
APR FC 0-5 Pyramids FC *
| 01.10.2025 | APR FC | 0-2 | Pyramids FC | |
| 05.10.2025 | Pyramids FC | 3-0 | APR FC | |