Kenya Police FC 1-4 Al Hilal Omdurman *
| 17.10.2025 | Kenya Police FC | 0-1 | Al Hilal Omdurman | |
| 24.10.2025 | Al Hilal Omdurman | 3-1 | Kenya Police FC | |
US Monastir 1-5 JS Kabylie *
| 17.10.2025 | US Monastir | 0-3 | JS Kabylie | |
| 25.10.2025 | JS Kabylie | 2-1 | US Monastir | |
Aigle Noir 0-2 Al Ahly Cairo *
| 18.10.2025 | Aigle Noir | 0-1 | Al Ahly Cairo | |
| 25.10.2025 | Al Ahly Cairo | 1-0 | Aigle Noir | |
Black Bulls 2-3 Rivers United *
| 18.10.2025 | Black Bulls | 1-0 | Rivers United | |
| 25.10.2025 | Rivers United | 3-1 | Black Bulls | |
Silver Strikers 1-2 Young Africans SC *
| 18.10.2025 | Silver Strikers | 1-0 | Young Africans SC | |
| 25.10.2025 | Young Africans SC | 2-0 | Silver Strikers | |
Stade d'Abidjan 0-4 Petro Atlético Luanda *
| 18.10.2025 | Stade d'Abidjan | 0-2 | Petro Atlético Luanda | |
| 25.10.2025 | Petro Atlético Luanda | 2-0 | Stade d'Abidjan | |
Rahimo FC 0-4 Esperance ST *
| 18.10.2025 | Rahimo FC | 0-1 | Esperance ST | |
| 26.10.2025 | Esperance ST | 3-0 | Rahimo FC | |
Colombe FC 1-1 MC Alger *
| 19.10.2025 | Colombe FC | 1-1 | MC Alger | |
| 26.10.2025 | MC Alger | 0-0 | Colombe FC | |
*Saint Eloi Lupopo 3-3 Orlando Pirates
| 19.10.2025 | Saint Eloi Lupopo | 3-0 | Orlando Pirates | |
| 25.10.2025 | Orlando Pirates | 3-0/p.4-5 | Saint Eloi Lupopo | |
Nsingizini Hotspurs FC 0-3 Simba SC *
| 19.10.2025 | Nsingizini Hotspurs FC | 0-3 | Simba SC | |
| 26.10.2025 | Simba SC | 0-0 | Nsingizini Hotspurs FC | |
Remo Stars 1-7 Mamelodi Sundowns *
| 19.10.2025 | Remo Stars | 1-5 | Mamelodi Sundowns | |
| 26.10.2025 | Mamelodi Sundowns | 2-0 | Remo Stars | |
Vipers SC 2-3 Power Dynamos *
| 19.10.2025 | Vipers SC | 1-2 | Power Dynamos | |
| 24.10.2025 | Power Dynamos | 1-1 | Vipers SC | |
FC Nouadhibou 1-3 Stade Malien *
| 19.10.2025 | FC Nouadhibou | 1-1 | Stade Malien | |
| 26.10.2025 | Stade Malien | 2-0 | FC Nouadhibou | |
Ethiopian Insurance 1-3 Pyramids FC *
| 26.10.2025 | Ethiopian Insurance | 1-1 | Pyramids FC | |
| 30.10.2025 | Pyramids FC | 2-0 | Ethiopian Insurance | |
Al Ahli Tripoli 2-3 Renaissance Berkane *
| 26.10.2025 | Al Ahli Tripoli | 1-1 | Renaissance Berkane | |
| 01.11.2025 | Renaissance Berkane | 2-1 | Al Ahli Tripoli | |