*CS La Mancha 4-2 Ahli Shandi
| 06.03.2018 | CS La Mancha | 3-0 | Ahli Shandi | |
| 16.03.2018 | Ahli Shandi | 2-1 | CS La Mancha | |
DC Motema Pembe 1-2 Deportivo Niefang *
| 06.03.2018 | DC Motema Pembe | 1-1 | Deportivo Niefang | |
| 18.03.2018 | Deportivo Niefang | 1-0 | DC Motema Pembe | |
Petro Atlético Luanda 1-2 SuperSport United *
| 06.03.2018 | Petro Atlético Luanda | 0-0 | SuperSport United | |
| 16.03.2018 | SuperSport United | 2-1 | Petro Atlético Luanda | |
*CR Belouizdad 3-1 Nkana FC
| 06.03.2018 | CR Belouizdad | 3-0 | Nkana FC | |
| 17.03.2018 | Nkana FC | 1-0 | CR Belouizdad | |
*Renaissance Berkane 4-1 Club Africain Tunis
| 06.03.2018 | Renaissance Berkane | 3-1 | Club Africain Tunis | |
| 17.03.2018 | Club Africain Tunis | 0-1 | Renaissance Berkane | |
*Raja Casablanca 5-3 FC Nouadhibou
| 06.03.2018 | Raja Casablanca | 1-1 | FC Nouadhibou | |
| 17.03.2018 | FC Nouadhibou | 2-4 | Raja Casablanca | |
AS Port-Louis 2000 0-3 Fosa Juniors *
| 07.03.2018 | AS Port-Louis 2000 | 0-2 | Fosa Juniors | |
| 18.03.2018 | Fosa Juniors | 1-0 | AS Port-Louis 2000 | |
AS Maniema Union 3-3 USM Alger *
| 07.03.2018 | AS Maniema Union | 2-2 | USM Alger | |
| 18.03.2018 | USM Alger | 1-1 | AS Maniema Union | |
Olympique Star 0-6 Hilal Ubayyid *
| 07.03.2018 | Olympique Star | 0-0 | Hilal Ubayyid | |
| 17.03.2018 | Hilal Ubayyid | 6-0 | Olympique Star | |
*Wolaitta Dicha 3-3 Zamalek SC
| 07.03.2018 | Wolaitta Dicha | 2-1 | Zamalek SC | |
| 18.03.2018 | Zamalek SC | 2-1/p.3-4 | Wolaitta Dicha | |
*CARA Brazzaville 4-3 US Ben Guerdane
| 07.03.2018 | CARA Brazzaville | 3-0 | US Ben Guerdane | |
| 18.03.2018 | US Ben Guerdane | 3-1 | CARA Brazzaville | |
Simba SC 2-2 Al Masry SC *
| 07.03.2018 | Simba SC | 2-2 | Al Masry SC | |
| 17.03.2018 | Al Masry SC | 0-0 | Simba SC | |
Energie FC 2-5 Enyimba Int'l FC *
| 07.03.2018 | Energie FC | 0-2 | Enyimba Int'l FC | |
| 18.03.2018 | Enyimba Int'l FC | 3-2 | Energie FC | |
Al Ittihad Tripoli 1-1 Akwa United *
| 07.03.2018 | Al Ittihad Tripoli | 1-0 | Akwa United | |
| 18.03.2018 | Akwa United | 1-0/p.3-2 | Al Ittihad Tripoli | |
*Costa do Sol Maputo 2-2 Cape Town City
| 07.03.2018 | Costa do Sol Maputo | 0-1 | Cape Town City | |
| 18.03.2018 | Cape Town City | 1-2 | Costa do Sol Maputo | |
*Djoliba AC 2-2 APR FC
| 07.03.2018 | Djoliba AC | 1-0 | APR FC | |
| 17.03.2018 | APR FC | 2-1 | Djoliba AC | |