*Anderlecht 3-1 Olympiakos Pireus
| 25.02.2016 | Olympiakos Pireus | 1-2 AET | Anderlecht | |
| 18.02.2016 | Anderlecht | 1-0 | Olympiakos Pireus | |
AS Saint-Étienne 4-4 FC Basel *
| 25.02.2016 | FC Basel | 2-1 | AS Saint-Étienne | |
| 18.02.2016 | AS Saint-Étienne | 3-2 | FC Basel | |
Olympique Marseille 1-2 Athletic Bilbao *
| 25.02.2016 | Athletic Bilbao | 1-1 | Olympique Marseille | |
| 18.02.2016 | Olympique Marseille | 0-1 | Athletic Bilbao | |
*Borussia Dortmund 3-0 FC Porto
| 25.02.2016 | FC Porto | 0-1 | Borussia Dortmund | |
| 18.02.2016 | Borussia Dortmund | 2-0 | FC Porto | |
*Fenerbahçe SK 3-1 Lokomotiv Moscow
| 25.02.2016 | Lokomotiv Moscow | 1-1 | Fenerbahçe SK | |
| 16.02.2016 | Fenerbahçe SK | 2-0 | Lokomotiv Moscow | |
Fiorentina 1-4 Tottenham *
| 25.02.2016 | Tottenham | 3-0 | Fiorentina | |
| 18.02.2016 | Fiorentina | 1-1 | Tottenham | |
Galatasaray SK 2-4 Lazio *
| 25.02.2016 | Lazio | 3-1 | Galatasaray SK | |
| 18.02.2016 | Galatasaray SK | 1-1 | Lazio | |
FC Augsburg 0-1 Liverpool *
| 25.02.2016 | Liverpool | 1-0 | FC Augsburg | |
| 18.02.2016 | FC Augsburg | 0-0 | Liverpool | |
FC Midtjylland 3-6 Manchester United *
| 25.02.2016 | Manchester United | 5-1 | FC Midtjylland | |
| 18.02.2016 | FC Midtjylland | 2-1 | Manchester United | |
*Valencia CF 10-0 Rapid Wien
| 25.02.2016 | Rapid Wien | 0-4 | Valencia CF | |
| 18.02.2016 | Valencia CF | 6-0 | Rapid Wien | |
*Shakhtar Donetsk 3-0 Schalke 04
| 25.02.2016 | Schalke 04 | 0-3 | Shakhtar Donetsk | |
| 18.02.2016 | Shakhtar Donetsk | 0-0 | Schalke 04 | |
*Sevilla FC 3-1 Molde FK
| 25.02.2016 | Molde FK | 1-0 | Sevilla FC | |
| 18.02.2016 | Sevilla FC | 3-0 | Molde FK | |
*Sparta Praha 4-0 FK Krasnodar
| 25.02.2016 | FK Krasnodar | 0-3 | Sparta Praha | |
| 18.02.2016 | Sparta Praha | 1-0 | FK Krasnodar | |
Sporting Lisboa 1-4 Bayer Leverkusen *
| 25.02.2016 | Bayer Leverkusen | 3-1 | Sporting Lisboa | |
| 18.02.2016 | Sporting Lisboa | 0-1 | Bayer Leverkusen | |
*Villarreal CF 2-1 SSC Napoli
| 25.02.2016 | SSC Napoli | 1-1 | Villarreal CF | |
| 18.02.2016 | Villarreal CF | 1-0 | SSC Napoli | |