Athletic Bilbao 3-3 Sevilla FC *
| 14.04.2016 | Sevilla FC | 1-2/p.5-4 | Athletic Bilbao | |
| 07.04.2016 | Athletic Bilbao | 1-2 | Sevilla FC | |
Borussia Dortmund 4-5 Liverpool *
| 14.04.2016 | Liverpool | 4-3 | Borussia Dortmund | |
| 07.04.2016 | Borussia Dortmund | 1-1 | Liverpool | |
SC Braga 1-6 Shakhtar Donetsk *
| 14.04.2016 | Shakhtar Donetsk | 4-0 | SC Braga | |
| 07.04.2016 | SC Braga | 1-2 | Shakhtar Donetsk | |
*Villarreal CF 6-3 Sparta Praha
| 14.04.2016 | Sparta Praha | 2-4 | Villarreal CF | |
| 07.04.2016 | Villarreal CF | 2-1 | Sparta Praha | |