FC Milsami 1-2 AS Saint-Étienne *
| 27.08.2015 | AS Saint-Étienne | 1-0 | FC Milsami | |
| 20.08.2015 | FC Milsami | 1-1 | AS Saint-Étienne | |
MSK Zilina 3-3 Athletic Bilbao *
| 27.08.2015 | Athletic Bilbao | 1-0 | MSK Zilina | |
| 20.08.2015 | MSK Zilina | 3-2 | Athletic Bilbao | |
Astra Giurgiu 3-4 AZ Alkmaar *
| 27.08.2015 | AZ Alkmaar | 2-0 | Astra Giurgiu | |
| 20.08.2015 | Astra Giurgiu | 3-2 | AZ Alkmaar | |
SCR Altach 0-1 Belenenses *
| 27.08.2015 | Belenenses | 0-0 | SCR Altach | |
| 20.08.2015 | SCR Altach | 0-1 | Belenenses | |
*Dinamo Minsk 2-2 RB Salzburg
| 27.08.2015 | RB Salzburg | 2-0/p.2-3 | Dinamo Minsk | |
| 20.08.2015 | Dinamo Minsk | 2-0 | RB Salzburg | |
Southampton 1-2 FC Midtjylland *
| 27.08.2015 | FC Midtjylland | 1-0 | Southampton | |
| 20.08.2015 | Southampton | 1-1 | FC Midtjylland | |
*Sparta Praha 6-4 FC Thun
| 27.08.2015 | FC Thun | 3-3 | Sparta Praha | |
| 20.08.2015 | Sparta Praha | 3-1 | FC Thun | |
Atromitos FC 0-4 Fenerbahçe SK *
| 27.08.2015 | Fenerbahçe SK | 3-0 | Atromitos FC | |
| 20.08.2015 | Atromitos FC | 0-1 | Fenerbahçe SK | |
*AFC Ajax 1-0 FK Jablonec
| 27.08.2015 | FK Jablonec | 0-0 | AFC Ajax | |
| 20.08.2015 | AFC Ajax | 1-0 | FK Jablonec | |
*FK Krasnodar 5-1 HJK Helsinki
| 27.08.2015 | HJK Helsinki | 0-0 | FK Krasnodar | |
| 20.08.2015 | FK Krasnodar | 5-1 | HJK Helsinki | |
*Viktoria Plzen 5-0 FK Vojvodina
| 27.08.2015 | FK Vojvodina | 0-2 | Viktoria Plzen | |
| 20.08.2015 | Viktoria Plzen | 3-0 | FK Vojvodina | |
*Girondins Bordeaux 2-2 Kairat Almaty
| 27.08.2015 | Kairat Almaty | 2-1 | Girondins Bordeaux | |
| 20.08.2015 | Girondins Bordeaux | 1-0 | Kairat Almaty | |
*Molde FK 3-3 Standard Liège
| 27.08.2015 | Standard Liège | 3-1 | Molde FK | |
| 20.08.2015 | Molde FK | 2-0 | Standard Liège | |
Odd BK 5-11 Borussia Dortmund *
| 27.08.2015 | Borussia Dortmund | 7-2 | Odd BK | |
| 20.08.2015 | Odd BK | 3-4 | Borussia Dortmund | |
*Gabala FC 2-2 Panathinaikos
| 27.08.2015 | Panathinaikos | 2-2 | Gabala FC | |
| 20.08.2015 | Gabala FC | 0-0 | Panathinaikos | |
*PAOK Salonica 6-1 Brøndby IF
| 27.08.2015 | Brøndby IF | 1-1 | PAOK Salonica | |
| 20.08.2015 | PAOK Salonica | 5-0 | Brøndby IF | |
BSC Young Boys 0-4 Qarabag FK *
| 27.08.2015 | Qarabag FK | 3-0 | BSC Young Boys | |
| 20.08.2015 | BSC Young Boys | 0-1 | Qarabag FK | |
Steaua Bucuresti 1-3 Rosenborg BK *
| 27.08.2015 | Rosenborg BK | 0-1 | Steaua Bucuresti | |
| 20.08.2015 | Steaua Bucuresti | 0-3 | Rosenborg BK | |
Rabotnicki Skopje 1-2 Rubin Kazan *
| 27.08.2015 | Rubin Kazan | 1-0 | Rabotnicki Skopje | |
| 20.08.2015 | Rabotnicki Skopje | 1-1 | Rubin Kazan | |
*Slovan Liberec 2-0 Hajduk Split
| 27.08.2015 | Hajduk Split | 0-1 | Slovan Liberec | |
| 20.08.2015 | Slovan Liberec | 1-0 | Hajduk Split | |
*Lech Poznan 4-0 Videoton FC
| 27.08.2015 | Videoton FC | 0-1 | Lech Poznan | |
| 20.08.2015 | Lech Poznan | 3-0 | Videoton FC | |
Zorya Luhansk 2-4 Legia Warszawa *
| 27.08.2015 | Legia Warszawa | 3-2 | Zorya Luhansk | |
| 20.08.2015 | Zorya Luhansk | 0-1 | Legia Warszawa | |