Atlético Nacional 1-1 São Paulo/SP *
| 20.08.2025 | São Paulo/SP | 1-1/p.4-3 | Atlético Nacional | |
| 13.08.2025 | Atlético Nacional | 0-0 | São Paulo/SP | |
Botafogo/RJ 1-2 LDU Quito *
| 22.08.2025 | LDU Quito | 2-0 | Botafogo/RJ | |
| 15.08.2025 | Botafogo/RJ | 1-0 | LDU Quito | |
CA Peñarol 2-3 Racing Club *
| 20.08.2025 | Racing Club | 3-1 | CA Peñarol | |
| 13.08.2025 | CA Peñarol | 1-0 | Racing Club | |
Cerro Porteño 0-1 Estudiantes La Plata *
| 21.08.2025 | Estudiantes La Plata | 0-0 | Cerro Porteño | |
| 14.08.2025 | Cerro Porteño | 0-1 | Estudiantes La Plata | |
*Flamengo/RJ 3-0 Internacional/RS
| 21.08.2025 | Internacional/RS | 0-2 | Flamengo/RJ | |
| 14.08.2025 | Flamengo/RJ | 1-0 | Internacional/RS | |
Fortaleza/CE 0-2 Vélez Sársfield *
| 20.08.2025 | Vélez Sársfield | 2-0 | Fortaleza/CE | |
| 13.08.2025 | Fortaleza/CE | 0-0 | Vélez Sársfield | |
Universitario 0-4 Palmeiras/SP *
| 22.08.2025 | Palmeiras/SP | 0-0 | Universitario | |
| 15.08.2025 | Universitario | 0-4 | Palmeiras/SP | |
Club Libertad 1-1 River Plate *
| 22.08.2025 | River Plate | 1-1/p.3-1 | Club Libertad | |
| 15.08.2025 | Club Libertad | 0-0 | River Plate | |