Club Tijuana 3-4 CF Monterrey *
| 06.05.2012 | CF Monterrey | 2-2 | Club Tijuana | |
| 03.05.2012 | Club Tijuana | 1-2 | CF Monterrey | |
Pachuca CF 2-3 Club América *
| 06.05.2012 | Club América | 0-1 | Pachuca CF | |
| 03.05.2012 | Pachuca CF | 1-3 | Club América | |
*Tigres UANL 5-1 Monarcas Morelia
| 07.05.2012 | Monarcas Morelia | 1-4 | Tigres UANL | |
| 04.05.2012 | Tigres UANL | 1-0 | Monarcas Morelia | |
Jaguares Chiapas 4-6 Santos Laguna *
| 07.05.2012 | Santos Laguna | 2-1 | Jaguares Chiapas | |
| 04.05.2012 | Jaguares Chiapas | 3-4 | Santos Laguna | |