| 04.03.2022 | |||
| 01:30 | Atlético Nacional | 1-1 | Olimpia Asunción |
| 03.03.2022 | |||
| 01:30 | Estudiantes La Plata | 2-0 | Audax Italiano |
| 01:30 | Universitario | 0-1 | Barcelona SC |
| 02.03.2022 | |||
| 23:15 | Club Guaraní | 2-3/p.4-5 | América Mineiro/MG |
| 23:15 | Univ. Católica Quito | 2-0 | Bolívar |
| 01:30 | Fluminense/RJ | 2-0 | Millonarios |
| 01:30 | The Strongest | 3-0 | Plaza Colonia |
| 01.03.2022 | |||
| 23:15 | Monagas SC | 1-0 | Everton Viña del Mar |
| 25.02.2022 | |||
| 01:30 | Olimpia Asunción | 3-1 | Atlético Nacional |
| 24.02.2022 | |||
| 01:30 | Audax Italiano | 1-0 | Estudiantes La Plata |
| 01:30 | Barcelona SC | 2-0 | Universitario |
| 23.02.2022 | |||
| 23:15 | América Mineiro/MG | 0-1 | Club Guaraní |
| 23:15 | Bolívar | 1-1 | Univ. Católica Quito |
| 01:30 | Millonarios | 1-2 | Fluminense/RJ |
| 01:30 | Plaza Colonia | 2-0 | The Strongest |
| 22.02.2022 | |||
| 23:15 | Everton Viña del Mar | 3-0 | Monagas SC |