Club América 1-2 Cruz Azul *
| 09.04.2025 | Cruz Azul | 2-1 | Club América | |
| 02.04.2025 | Club América | 0-0 | Cruz Azul | |
Los Angeles FC 2-3 Inter Miami CF *
| 10.04.2025 | Inter Miami CF | 3-1 | Los Angeles FC | |
| 03.04.2025 | Los Angeles FC | 1-0 | Inter Miami CF | |
Los Angeles Galaxy 2-3 Tigres UANL *
| 09.04.2025 | Tigres UANL | 3-2 | Los Angeles Galaxy | |
| 02.04.2025 | Los Angeles Galaxy | 0-0 | Tigres UANL | |
*Vancouver WC 3-3 UNAM Pumas
| 10.04.2025 | UNAM Pumas | 2-2 | Vancouver WC | |
| 03.04.2025 | Vancouver WC | 1-1 | UNAM Pumas | |