Brujas FC 4-6 Joe Public FC *
| 06.08.2010 | Joe Public FC | 4-2 | Brujas FC | |
| 29.07.2010 | Brujas FC | 2-2 | Joe Public FC | |
*CD FAS 3-1 Club Xelajú MC
| 06.08.2010 | Club Xelajú MC | 0-2 | CD FAS | |
| 30.07.2010 | CD FAS | 1-1 | Club Xelajú MC | |
*Toronto FC 3-2 CD Motagua
| 04.08.2010 | CD Motagua | 2-2 | Toronto FC | |
| 28.07.2010 | Toronto FC | 1-0 | CD Motagua | |
San Francisco FC 2-9 Cruz Azul *
| 04.08.2010 | Cruz Azul | 6-0 | San Francisco FC | |
| 28.07.2010 | San Francisco FC | 2-3 | Cruz Azul | |
*Seattle Sounders 2-1 Isidro Metapán
| 04.08.2010 | Isidro Metapán | 1-1 | Seattle Sounders | |
| 29.07.2010 | Seattle Sounders | 1-0 | Isidro Metapán | |
Los Angeles Galaxy 3-5 Puerto Rico Islanders *
| 05.08.2010 | Puerto Rico Islanders | 1-2 | Los Angeles Galaxy | |
| 28.07.2010 | Los Angeles Galaxy | 1-4 | Puerto Rico Islanders | |
San Juan Jabloteh 0-6 Santos Laguna *
| 05.08.2010 | Santos Laguna | 5-0 | San Juan Jabloteh | |
| 28.07.2010 | San Juan Jabloteh | 0-1 | Santos Laguna | |
Tauro FC 2-4 CD Marathón *
| 05.08.2010 | CD Marathón | 1-2 | Tauro FC | |
| 29.07.2010 | Tauro FC | 0-3 | CD Marathón | |