CA Lanús 2-3 Club Atlas *
| 07.05.2008 | Club Atlas | 2-2 | CA Lanús | |
| 30.04.2008 | CA Lanús | 0-1 | Club Atlas | |
*Boca Juniors 4-2 Cruzeiro/MG
| 08.05.2008 | Cruzeiro/MG | 1-2 | Boca Juniors | |
| 30.04.2008 | Boca Juniors | 2-1 | Cruzeiro/MG | |
*LDU Quito 3-2 Estudiantes La Plata
| 07.05.2008 | Estudiantes La Plata | 2-1 | LDU Quito | |
| 30.04.2008 | LDU Quito | 2-0 | Estudiantes La Plata | |
*Club América 5-4 Flamengo/RJ
| 08.05.2008 | Flamengo/RJ | 0-3 | Club América | |
| 01.05.2008 | Club América | 2-4 | Flamengo/RJ | |
Atlético Nacional 1-3 Fluminense/RJ *
| 06.05.2008 | Fluminense/RJ | 1-0 | Atlético Nacional | |
| 01.05.2008 | Atlético Nacional | 1-2 | Fluminense/RJ | |
*San Lorenzo 4-3 River Plate
| 09.05.2008 | River Plate | 2-2 | San Lorenzo | |
| 01.05.2008 | San Lorenzo | 2-1 | River Plate | |
*Santos/SP 4-0 Cúcuta Deportivo
| 09.05.2008 | Cúcuta Deportivo | 0-2 | Santos/SP | |
| 02.05.2008 | Santos/SP | 2-0 | Cúcuta Deportivo | |
Nacional (URU) 0-2 São Paulo/SP *
| 08.05.2008 | São Paulo/SP | 2-0 | Nacional (URU) | |
| 01.05.2008 | Nacional (URU) | 0-0 | São Paulo/SP | |