Manchester United 3-5 Athletic Bilbao *
| 15.03.2012 | Athletic Bilbao | 2-1 | Manchester United | |
| 08.03.2012 | Manchester United | 2-3 | Athletic Bilbao | |
*AZ Alkmaar 3-2 Udinese Calcio
| 15.03.2012 | Udinese Calcio | 2-1 | AZ Alkmaar | |
| 08.03.2012 | AZ Alkmaar | 2-0 | Udinese Calcio | |
*Atlético Madrid 6-1 Besiktas JK
| 15.03.2012 | Besiktas JK | 0-3 | Atlético Madrid | |
| 08.03.2012 | Atlético Madrid | 3-1 | Besiktas JK | |
Standard Liège 2-6 Hannover 96 *
| 15.03.2012 | Hannover 96 | 4-0 | Standard Liège | |
| 08.03.2012 | Standard Liège | 2-2 | Hannover 96 | |
*Sporting Lisboa 3-3 Manchester City
| 15.03.2012 | Manchester City | 3-2 | Sporting Lisboa | |
| 08.03.2012 | Sporting Lisboa | 1-0 | Manchester City | |
*Metalist Kharkiv 2-2 Olympiakos Pireus
| 15.03.2012 | Olympiakos Pireus | 1-2 | Metalist Kharkiv | |
| 08.03.2012 | Metalist Kharkiv | 0-1 | Olympiakos Pireus | |
*Valencia CF 5-3 PSV Eindhoven
| 15.03.2012 | PSV Eindhoven | 1-1 | Valencia CF | |
| 08.03.2012 | Valencia CF | 4-2 | PSV Eindhoven | |
FC Twente 2-4 Schalke 04 *
| 15.03.2012 | Schalke 04 | 4-1 | FC Twente | |
| 08.03.2012 | FC Twente | 1-0 | Schalke 04 | |