| 20.02.2022 | |||
| 00:00 | Albion FC (URU) | 1-1 | CA Peñarol |
| 19.02.2022 | |||
| 21:00 | Defensor Sporting | 1-3 | Montevideo City Torque |
| 13:30 | River Plate (URU) | 1-2 | Boston River |
| 00:00 | Cerro Largo | 0-5 | Plaza Colonia |
| 15.02.2022 | |||
| 01:30 | CD Maldonado | 1-2 | Danubio FC |
| 14.02.2022 | |||
| 23:15 | Mvo Wanderers | 1-0 | Cerro Largo |
| 00:05 | CA Peñarol | 0-1 | Defensor Sporting |
| 13.02.2022 | |||
| 21:00 | Boston River | 0-1 | CS Cerrito |
| 13:30 | Liverpool (URU) | 4-0 | Albion FC (URU) |
| 00:00 | CA Rentistas | 0-4 | Nacional (URU) |
| 12.02.2022 | |||
| 21:00 | Plaza Colonia | 0-1 | River Plate (URU) |
| 00:15 | Montevideo City Torque | 1-2 | CA Fénix |
| 09.02.2022 | |||
| 00:00 | CS Cerrito | 0-1 | Danubio FC |
| 07.02.2022 | |||
| 21:00 | River Plate (URU) | 1-1 | Mvo Wanderers |
| 00:00 | Nacional (URU) | 2-3 | CD Maldonado |
| 06.02.2022 | |||
| 21:00 | Boston River | 0-0 | Plaza Colonia |
| 13:30 | Albion FC (URU) | 3-5 | CA Rentistas |
| 05.02.2022 | |||
| 23:30 | Defensor Sporting | 0-3 | Liverpool (URU) |
| 21:00 | CA Fénix | 1-0 | CA Peñarol |
| 13:30 | Montevideo City Torque | 1-1 | Cerro Largo |