New York Red Bulls 2-6 Santos Laguna *
| 06.03.2019 | New York Red Bulls | 0-2 | Santos Laguna | |
| 13.03.2019 | Santos Laguna | 4-2 | New York Red Bulls | |
Houston Dynamo 0-3 Tigres UANL *
| 06.03.2019 | Houston Dynamo | 0-2 | Tigres UANL | |
| 13.03.2019 | Tigres UANL | 1-0 | Houston Dynamo | |
CAI de La Chorrera 2-4 Sporting Kansas City *
| 07.03.2019 | CAI de La Chorrera | 2-1 | Sporting Kansas City | |
| 15.03.2019 | Sporting Kansas City | 3-0 | CAI de La Chorrera | |
*CF Monterrey 3-1 Atlanta United
| 07.03.2019 | CF Monterrey | 3-0 | Atlanta United | |
| 14.03.2019 | Atlanta United | 1-0 | CF Monterrey | |