Atlético Pantoja 0-5 New York Red Bulls *
| 28.02.2019 | New York Red Bulls | 3-0 | Atlético Pantoja | |
| 21.02.2019 | Atlético Pantoja | 0-2 | New York Red Bulls | |
CAI de La Chorrera 5-1 Toronto FC *
| 27.02.2019 | Toronto FC | 1-1 | CAI de La Chorrera | |
| 20.02.2019 | CAI de La Chorrera | 4-0 | Toronto FC | |
CD Marathón 2-11 Santos Laguna *
| 28.02.2019 | Santos Laguna | 5-0 | CD Marathón | |
| 21.02.2019 | CD Marathón | 2-6 | Santos Laguna | |
Alianza FC (SLV) 0-1 CF Monterrey *
| 28.02.2019 | CF Monterrey | 1-0 | Alianza FC (SLV) | |
| 21.02.2019 | Alianza FC (SLV) | 0-0 | CF Monterrey | |
CS Herediano 3-5 Atlanta United *
| 01.03.2019 | Atlanta United | 4-0 | CS Herediano | |
| 22.02.2019 | CS Herediano | 3-1 | Atlanta United | |
Deportivo Guastatoya 1-3 Houston Dynamo *
| 27.02.2019 | Houston Dynamo | 2-1 | Deportivo Guastatoya | |
| 20.02.2019 | Deportivo Guastatoya | 0-1 | Houston Dynamo | |
*Sporting Kansas City 5-0 Deportivo Toluca
| 01.03.2019 | Deportivo Toluca | 0-2 | Sporting Kansas City | |
| 22.02.2019 | Sporting Kansas City | 3-0 | Deportivo Toluca | |
Saprissa 2-5 Tigres UANL *
| 27.02.2019 | Tigres UANL | 5-1 | Saprissa | |
| 20.02.2019 | Saprissa | 1-0 | Tigres UANL | |